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Dietary prevention of allergic diseases in infants and small children : Amendment to previous published articles in Pediatric Allergy and Immunology 2004, by an expert group set up by the Section on Pediatrics, European Academy of Allergology and Clinical Immunology

Host, A. (författare)
Høst, A., Department of Pediatrics, Odense University Hospital, Odense, Denmark
Halken, S. (författare)
Department of Pediatrics, Odense University Hospital, Odense, Denmark
Muraro, A. (författare)
Department of Pediatrics, University of Padua, Padua, Italy, Department of Pediatrics, University of Padua, Via Giustiniani 3, 35128 Padua, Italy
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Dreborg, S. (författare)
ESPACI, Lerum, Sweden
Niggemann, B. (författare)
Department of Pneumology and Immunology, University Children's Hospital Charité, Humboldt University, Berlin, Germany
Aalberse, R. (författare)
Department of Allergy CLB, Amsterdam, Netherlands
Arshad, S.H. (författare)
Clinical Allergy Research Unit, St. Mary's Hospital, Newport, Isle of Wight, United Kingdom
Von, Berg A. (författare)
Von Berg, A., Abt. für Kinderheilkunde, Marien-Hospital, Wesel, Germany
Carlsen, K.-H. (författare)
Voksentoppen National Centre of Asthma, Allergy and Chronic, Lung Diseases in Children, Oslo, Norway
Duchen, Karel (författare)
Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
Eigenmann, P.A. (författare)
Allergologie/Pediatrie, University of Geneve, Geneve, Switzerland
Hill, D. (författare)
Department of Allergy, Royal Children's Hospital, North Melbourne, VIC, Australia
Jones, C. (författare)
Child Health, Southampton General Hospital, (803) Centre Block, Southampton, United Kingdom
Mellon, M. (författare)
Kaiser Permanente San Diego, San Diego, CA, United States
Oldeus, G. (författare)
Department of Paediatrics, County Hospital Ryhov, Jönköping, Sweden
Oranje, A. (författare)
Department of Dermatology and Venerology, ErasmusMC-University Medical Center, Sophia Children's Hospital Rotterdam, Rotterdam, Netherlands
Pascual, C. (författare)
Servicio de Alergia, Hospital Infantil Universitario La Paz, Madrid, Spain
Prescott, S. (författare)
Department of Paediatrics, University of Western Australia, Subiaco, WA, Australia
Sampson, H. (författare)
Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY, United States
Svartengren, M. (författare)
Department of Public Health Sciences, Division of Occupational Medicine, Karolinska Hospital, Stockholm, Sweden
Wahn, U. (författare)
A.Z.- Kinderen, Free University of Brussels, Brussels, Belgium
Warner, J.A. (författare)
Child Health, Southampton General Hospital, (803) Centre Block, Southampton, United Kingdom
Warner, J.O. (författare)
Child Health, Southampton General Hospital, (803) Centre Block, Southampton, United Kingdom
Vandenplas, Y. (författare)
A.Z.- Kinderen, Free University of Brussels, Brussels, Belgium
Wickman, M. (författare)
Department of Environmental Health, Karolinska Hospital, Stockholm, Sweden
Zeiger, R.S. (författare)
Kaiser Permanente San Diego, San Diego, CA, United States
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Høst, A, Department of Pediatrics, Odense University Hospital, Odense, Denmark Department of Pediatrics, Odense University Hospital, Odense, Denmark (creator_code:org_t)
2008-01-10
2008
Engelska.
Ingår i: Pediatric Allergy and Immunology. - : Wiley. - 0905-6157 .- 1399-3038. ; 19:1
  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
Stäng  
  • Because of scientific fraud four trials have been excluded from the original Cochrane meta-analysis on formulas containing hydrolyzed protein for prevention of allergy and food intolerance in infants. Unlike the conclusions of the revised Cochrane review the export group set up by the Section on Paediatrics, European Academy of Allergology and Clinical Immunology (SP-EAACI) do not find that the exclusion of the four trials demands a change of the previous recommendations regarding primary dietary prevention of allergic diseases. Ideally, recommendations on primary dietary prevention should be based only on the results of randomized and quasi-randomized trials (selection criteria in the Cochrane review). However, regarding breastfeeding randomization is unethical, Therefore, in the development of recommendations on dietary primary prevention, high-quality systematic reviews of high-quality cohort studies should be included in the evidence base. The study type combined with assessment of the methodological quality determines the level of evidence. In view of some methodological concerns in the Cochrane meta-analysis, particularly regarding definitions and diagnostic criteria for outcome measures and inclusion of non peer-reviewed studies/reports, a revision of the Cochrane analysis may seem warranted. Based on analysis of published peer-reviewed observational and interventional studies the results still indicate that breastfeeding is highly recommended for all infants irrespective of atopic heredity. A dietary regimen is effective in the prevention of allergic diseases in high-risk infants, particularly in early infancy regarding food allergy and eczema. The most effective dietary regimen is exclusively breastfeeding for at least 4-6 months or, in absence of breast milk, formulas with documented reduced allergenicity for at least the first 4 months, combined with avoidance of solid food and cow's milk for the first 4 months. © 2008 The Authors.

Nyckelord

Atopy
Breast feeding
Cow's milk allergy
Eczema
Food allergy
Prevention
Review
Statements of evidence
NATURAL SCIENCES
NATURVETENSKAP

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