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  • Schulman, S.Karolinska Institutet (författare)

Post-thrombotic syndrome, recurrence, and death 10 years after the first episode of venous thromboembolism treated with warfarin for 6 weeks or 6 months

  • Artikel/kapitelEngelska2006

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2006
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-48055
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-48055URI
  • https://doi.org/10.1111/j.1538-7836.2006.01795.xDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1936515URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: The influence of the duration of anticoagulant therapy after venous thromboembolism (VTE) on the long-term morbidity and mortality is unclear. Aim: To investigate the long-term sequelae of VTE in patients randomized to different duration of secondary prophylaxis. Methods: In a multicenter trial comparing secondary prophylaxis with vitamin K antagonists for 6 weeks or 6 months, we extended the originally planned 2 years follow-up to 10 years. The patients had annual visits and at the last visit clinical assessment of the post-thrombotic syndrome (PTS) was performed. Recurrent thromboembolism was adjudicated by a radiologist, blinded to treatment allocation. Causes of death were obtained from the Swedish Death Registry. Results: Of the 897 patients randomized, 545 could be evaluated at the 10 years follow-up. The probability of developing severe PTS was 6% and any sign of PTS was seen in 56.3% of the evaluated patients. In multivariate analysis, old age and signs of impaired circulation at discharge from the hospital were independent risk factors at baseline for development of PTS after 10 years. Recurrent thromboembolism occurred in 29.1% of the patients with a higher rate among males, older patients, those with permanent gering risk factor - especially with venous insufficiency at baseline - signs of impaired venous circulation at discharge, proximal deep vein thrombosis, or pulmonary embolism. Death occurred in 28.5%, which was a higher mortality than expected with a standardized incidence ratio (SIR) of 1.43 (95% CI 1.28-1.58), mainly because of a higher mortality than expected from cancer (SIR 1.83, 95% CI 1.44-2.23) or from myocardial infarction or stroke (SIR 1.28, 95% CI 1.00-1.56).The duration of anticoagulation did not have a statistically significant effect on any of the long-term outcomes. Conclusion: The morbidity and mortality during 10 years after the first episode of VTE is high and not reduced by extension of secondary prophylaxis from 6 weeks to 6 months. A strategy to reduce recurrence of VTE as well as mortality from arterial disease is needed. © 2006 International Society on Thrombosis and Haemostasis.

Ämnesord och genrebeteckningar

  • Death
  • Deep vein thrombosis
  • Myocardial infarction
  • Post-thrombotic syndrome
  • Pulmonary embolism
  • Recurrence
  • Stroke
  • Warfarin
  • NATURAL SCIENCES
  • NATURVETENSKAP

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lindmarker, P.Department of Emergency Medicine, Karolinska University Hospital, Karolinska, Sweden (författare)
  • Holmstrom, M.Karolinska Institutet (författare)
  • Lafars, G.Karolinska Institutet (författare)
  • Carlsson, A.Department of Hematology, Coagulation Unit, Karolinska University Hospital, Stockholm, Sweden, Danderyd Hospital, Danderyd, Sweden (författare)
  • Nicol, P.Köping Hospital, Köping, Sweden (författare)
  • Svensson, E.Södertälje Hospital, Södertälje, Sweden (författare)
  • Ljungberg, B.Nyköping Hospital, Nyköping, Sweden (författare)
  • Viering, S.Norrtälje Hospital, Norrtälje, Sweden (författare)
  • Nordlander, S.Västerås Central Hospital, Västerås, Sweden (författare)
  • Leijd, B.St. Göran Hospital, Sweden (författare)
  • Jahed, K.Östergötlands Läns Landsting (författare)
  • Hjorth, M.Lidköping Hospital, Lidköping, Sweden (författare)
  • Linder, O.Örebro Regional Hospital, Örebro, Sweden (författare)
  • Beckman, M.Department of Radiology, Karolinska University Hospital, Stockholm, Sweden (författare)
  • Karolinska InstitutetDepartment of Emergency Medicine, Karolinska University Hospital, Karolinska, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Thrombosis and Haemostasis: Elsevier BV4:4, s. 734-7421538-79331538-7836

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