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Chronomodulated cap...
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Qvortrup, C.Department of Oncology, Odense University Hospital, Sdr. Boulevard 29, Odense C 5000, Denmark, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
(författare)
Chronomodulated capecitabine in combination with short-time oxaliplatin : A Nordic phase II study of second-line therapy in patients with metastatic colorectal cancer after failure to irinotecan and 5-flourouracil
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
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Elsevier BV,2008
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-48765
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-48765URI
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https://doi.org/10.1093/annonc/mdn002DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105354URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Oxaliplatin in combination with capecitabine prolongs survival in patients with metastatic colorectal cancer (mCRC). Chronomodulation might reduce toxicity and improve efficacy. Patients and methods: A phase II study examining chronomodulated XELOX30 (XELOX30chron): oxaliplatin: 130 mg/m2 on day 1, as a 30-min infusion between 1 and 3 p.m. Capecitabine: total daily dose of 2000 mg/m2, 20% of the dose between 7 and 9 a.m. and 80% of the dose between 6 and 8 p.m. in patients with mCRC resistant to irinotecan. Seventy-one patients were enrolled. Response rate was 18%, median progression-free survival 5.1 months and median overall survival (OS) 10.2 months. Platelet count and performance status were significantly correlated to OS in multivariate analyses. Neurotoxicity grade 2 and 3 was seen in 25% and 2% of patients, respectively, other grade 3 toxic effects were as follows: nausea 6%, vomiting 3%, diarrhoea 12% (3% experienced grade 4) and palmoplantart erytem 9%. Conclusion: XELOX30chron is a convenient second-line regimen with efficacy and safety profile similar to other oxaliplatin schedules. To further investigate chronomodulated XELOX, we have started a Nordic randomised phase II study comparing XELOX30 and XELOX30chron as first-line therapy in patients with mCRC. © The Author 2008. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
Ämnesord och genrebeteckningar
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Capecitabine
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Chronotherapy
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Metastatic colorectal cancer
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Oxaliplatin
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Short-time infusion
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XELOX
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NATURAL SCIENCES
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NATURVETENSKAP
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MEDICINE
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Yilmaz, M.Department of Oncology, Aalborg University Hospital, Aalborg, Denmark
(författare)
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Ogreid, D.Department of Oncology, Rogaland Central Hospital, Stavanger, Norway
(författare)
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Berglund, ÅkeUppsala universitet,Enheten för onkologi,Ake Berglund(Swepub:uu)akebergl
(författare)
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Balteskard, L.Department of Oncology, Tromso University Hospital, Tromso, Norway
(författare)
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Ploen, J.Department of Oncology, Vejle Hospital, Vejle, Denmark
(författare)
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Fokstuen, T.Department of Oncology and Pathology, Karolinska Hospital, Stockholm, Sweden
(författare)
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Starkhammar, HansÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)hanst87
(författare)
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Sorbye, H.Sørbye, H., Department of Oncology, Haukeland University Hospital, Bergen, Norway
(författare)
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Tveit, K.Department of Oncology, Ullevål University Hospital, Oslo, Norway
(författare)
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Pfeiffer, P.Department of Oncology, Odense University Hospital, Sdr. Boulevard 29, Odense C 5000, Denmark
(författare)
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Department of Oncology, Odense University Hospital, Sdr. Boulevard 29, Odense C 5000, Denmark, Institute of Clinical Research, University of Southern Denmark, Odense, DenmarkDepartment of Oncology, Aalborg University Hospital, Aalborg, Denmark
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Annals of Oncology: Elsevier BV19:6, s. 1154-11590923-75341569-8041
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Till lärosätets databas
- Av författaren/redakt...
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Qvortrup, C.
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Yilmaz, M.
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Ogreid, D.
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Berglund, Åke
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Balteskard, L.
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Ploen, J.
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visa fler...
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Fokstuen, T.
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Starkhammar, Han ...
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Sorbye, H.
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Tveit, K.
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Pfeiffer, P.
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Annals of Oncolo ...
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Linköpings universitet
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Uppsala universitet