β-Carotene Uptake and Bioconversion to Retinol Differ Between Human Melanocytes and Keratinocytes

Andersson, EvaLinköpings universitet,Dermatologi,Hälsouniversitetet (författare)

β-Carotene is one of the carotenoids that has been considered to play a role in the natural defense against ultraviolet-induced skin cancer. It is not known whether epidermal cells are able to accumulate β-carotene and, subsequently, convert it to vitamin A. We used normal cultured human keratinocytes and melanocytes to study the uptake, and possible bioconversion to retinol, of authentic or [14C]β-carotene. The uptake was much higher in melanocytes than in keratinocytes, corresponding to a fivefold difference in the intracellular fraction after two days of incubation. An increased level of cellular retinol was noted after one day of β-carotene incubation. The conversion of [C]β-carotene to [14C]retinol peaked at 24 hours of incubation in keratinocytes and melanocytes. The results suggest that β-carotene can function as a local supply of vitamin A in the skin and that melanocytes are especially likely to store β-carotene.

Vahlquist, AndersSection of Dermatology and Venereology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden (författare)
Rosdahl, IngerLinköpings universitet,Dermatologi,Hälsouniversitetet(Swepub:liu)ingro22 (författare)
Linköpings universitetDermatologi (creator_code:org_t)

Av författaren/redakt...: Andersson, Eva; Vahlquist, Ander ...; Rosdahl, Inger

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.