Deletion mapping of chromosome segment 11q24-q25, exhibiting extensive allelic loss in early onset breast cancer

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Gentile, MassimilianoLinköpings universitet,Onkologi,Hälsouniversitetet (författare)

Deletion mapping of chromosome segment 11q24-q25, exhibiting extensive allelic loss in early onset breast cancer

Artikel/kapitelEngelska2001

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2001
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Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:liu-49326
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-49326URI
https://doi.org/10.1002/1097-0215(200102)9999:9999<::AID-IJC1169>3.0.CO;2-4DOI
https://lup.lub.lu.se/record/1121215URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

Anmärkningar

Frequent allelic deletions at chromosome 11q24-q25 have been described in both early and late onset breast cancers, suggesting the existence of a gene locus implicated in the initiation and/or progression of the disease. In the present study we fine mapped this region further by loss of heterozygosity (LOH) analysis in a population of early onset breast cancer cases (n = 102, 22 to 36 years old). Loss of chromosomal material was assessed for possible association with patient survival as well as Nottingham histologic grade (NHG). Additionally, we investigated the involvement of the 11q24-q25 locus in a group of familial breast cancer cases with no detectable BRCA1 or BRCA2 gene alterations (n = 32, ages 28 to 40 years). Among the consecutive patients, extensive LOH was observed for all markers at 11q24-q25, with frequencies ranging from 42% to 54%. Deletion at the D11S4125 marker was found to be associated with reduced survival (p = 0.026), whereas the adjacent D11S387 marker correlated with higher histologic grade (p = 0.042). In the familial cases, the most telomeric markers showed substantially lower proportions of LOH, ranging from 10% to 21%. Comparison of the two patient groups demonstrated that this difference in LOH frequency was statistically significant for the D11S4098, D11S968, D11S387 and D11S4125 markers (p = 0.020, p = 0.029, p = 0.0070 and p = 0.0030, respectively). We conclude that 11q25 may harbor a gene implicated in early onset breast cancer. Our data suggest that the most probable position for this locus is defined by the markers D11S387 and D11S4125 and furthermore that it may play a less significant role in familial breast cancer cases not linked to either of the BRCA genes.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
11q
LOH
early onset
familial breast cancer
prognosis
young age
MEDICINE
MEDICIN
11q
LOH
early onset
familial breast cancer
prognosis
young age

Biuppslag (personer, institutioner, konferenser, titlar ...)

Wiman, ÅsaLinköpings universitet,Onkologi,Hälsouniversitetet (författare)
Thorstenson, StenDepartment of Pathology and Cytology, Kalmar County Hospital, Kalmar, Sweden(Swepub:liu)steth53 (författare)
Loman, NiklasLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Oncology, Jubileum Institute, University Hospital, Lund, Sweden(Swepub:lu)onk-nlo (författare)
Borg, ÅkeLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Oncology, Jubileum Institute, University Hospital, Lund, Sweden(Swepub:lu)onk-abo (författare)
Wingren, StenLinköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)stewi96 (författare)
Linköpings universitetOnkologi (creator_code:org_t)

Sammanhörande titlar

Ingår i:International Journal of Cancer92:2, s. 208-2130020-71361097-0215

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Av författaren/redakt...: Gentile, Massimi ...; Wiman, Åsa; Thorstenson, Ste ...; Loman, Niklas; Borg, Åke; Wingren, Sten

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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Av lärosätet: Linköpings universitet; Lunds universitet

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