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Multiple HIV-1 intr...
Multiple HIV-1 introductions into the Swedish intravenous drug user population
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- Skar, H. (författare)
- Karolinska Institutet,Department of Virology, Swedish Institute for Infectious Disease Control, SE-17182 Solna, Sweden, Department of Microbiology Tumor and Cell Biology, Karolinska Institute, SE-17177 Stockholm, Sweden, Theoretical Biology and Biophysics, Group T-10, Los Alamos National Laboratory, MS K710, Los Alamos, NM 87545, United States
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- Sylvan, S. (författare)
- Regional Center for Infectious Disease Control and Prevention, Dag Hammarskjölds väg 17, SE-751 85 Uppsala, Sweden
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- Hansson, Hans-Bertil (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Regional Center for Infectious Disease Control and Prevention, University Hospital MAS, SE-20502 Malmö, Sweden
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- Gustavsson, Olle (författare)
- Östergötlands Läns Landsting,Klinisk mikrobiologi
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- Boman, H. (författare)
- Department of Communicable Diseases Control, Sundsvall Hospital, SE-851 86 Sundsvall, Sweden
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- Albert, J. (författare)
- Karolinska Institutet,Department of Virology, Swedish Institute for Infectious Disease Control, SE-17182 Solna, Sweden, Department of Microbiology Tumor and Cell Biology, Karolinska Institute, SE-17177 Stockholm, Sweden
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- Leitner, T. (författare)
- Theoretical Biology and Biophysics, Group T-10, Los Alamos National Laboratory, MS K710, Los Alamos, NM 87545, United States
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: Infection, Genetics and Evolution. - : Elsevier BV. - 1567-1348 .- 1567-7257. ; 8:5, s. 545-552
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http://dx.doi.org/10...
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Abstract
Ämnesord
Stäng
- In 2001, an increase of HIV-1 diagnoses among intravenous drug users (IVDU) was reported in Sweden. In nearby countries, Finland, Russia and the Baltic states, recent outbreaks had been described. Since there was a concern that these outbreaks would carry over to Sweden a study was initiated to determine the factors leading to the Swedish increase of HIV-1 diagnosed IVDUs. HIV-1 env V3 sequences were obtained from 97 patients enrolled in ongoing epidemiological studies encompassing the years 1987-2004 with a focus on 2001-2002. The sequences were used for maximum likelihood and Bayesian inference of the molecular epidemiology. Among the virus spreading in 2001-2002, we found that four different subtypes/CRFs were present in the Swedish IVDU population (A, B, CRF01_AE and CRF06_cpx). Subtype B constituted 85% of the infections, established by 12 independent introductions into the IVDU population. The worrisome increase in 2001 was mainly not a result of import of the outbreaks in nearby countries, but rather a higher detection rate of secondary cases due to efficient epidemiological tracing of the generally slow spread of established forms of subtype B in the IVDU community. However, a few of the non-subtype B cases were linked to the outbreaks in Finland, Estonia and Latvia. Because HIV-1 outbreaks can easily be exported from one country to another amongst IVDUs, this prompts continued surveillance in the Baltic Sea Region.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Evolutionary rate
- HIV-1
- Intravenous drug users
- Molecular epidemiology
- Outbreak
- Phylogeny
- Tree node height
- MEDICINE
- MEDICIN
- Intravenous drug users
- Tree node height
- Phylogeny
- Evolutionary rate
- Outbreak
- HIV-1
- Molecular epidemiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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