Material properties of the ovine mitral valve anterior leaflet in vivo from inverse finite element analysis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Bothe C) > Material properties...

Details
MARC

Krishnamurthy, G.Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States, Department of Mechanical Engineering, Stanford University, Stanford, CA, United States (author)

Material properties of the ovine mitral valve anterior leaflet in vivo from inverse finite element analysis

Article/chapterEnglish2008

Publisher, publication year, extent ...

American Physiological Society,2008
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:liu-50387
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-50387URI
https://doi.org/10.1152/ajpheart.00284.2008DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

We measured leaflet displacements and used inverse finite-element analysis to define, for the first time, the material properties of mitral valve (MV) leaflets in vivo. Sixteen miniature radiopaque markers were sewn to the MV annulus, 16 to the anterior MV leaflet, and 1 on each papillary muscle tip in 17 sheep. Four-dimensional coordinates were obtained from biplane videofluoroscopic marker images (60 frames/s) during three complete cardiac cycles. A finite-element model of the anterior MV leaflet was developed using marker coordinates at the end of isovolumic relaxation (IVR, when the pressure difference across the valve is ~0), as the minimum stress reference state. Leaflet displacements were simulated during IVR using measured left ventricular and atrial pressures. The leaflet shear modulus (Gcirc-rad) and elastic moduli in both the commisure-commisure (Ecirc) and radial (Erad) directions were obtained using the method of feasible directions to minimize the difference between simulated and measured displacements. Group mean (±SD) values (17 animals, 3 heartbeats each, i.e., 51 cardiac cycles) were as follows: Gcirc-rad = 121 ± 22 N/mm2, Ecirc = 43 ± 18 N/mm2, and Erad = 11 ± 3 N/mm2 (Ecirc > E rad, P < 0.01). These values, much greater than those previously reported from in vitro studies, may result from activated neurally controlled contractile tissue within the leaflet that is inactive in excised tissues. This could have important implications, not only to our understanding of mitral valve physiology in the beating heart but for providing additional information to aid the development of more durable tissue-engineered bioprosthetic valves. Copyright © 2008 the American Physiological Society.

Subject headings and genre

Inverse finite-element analysis
Mitral valve material properties
Ovine model
Radiopaque markers
TECHNOLOGY
TEKNIKVETENSKAP

Added entries (persons, corporate bodies, meetings, titles ...)

Ennis, D.B.Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States (author)
Itoh, A.Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States (author)
Bothe, W.Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States (author)
Swanson, J.C.Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States (author)
Karlsson, MattsLinköpings universitet,Mekanisk värmeteori och strömningslära,Tekniska högskolan(Swepub:liu)matka16 (author)
Kuh, E.Department of Mechanical Engineering, Stanford University, Stanford, CA, United States (author)
Miller, D.C.Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States (author)
Ingels, Jr. N.B.Ingels Jr., N.B., Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States, Laboratory of Cardiovascular Physiology and Biophysics, Research Institute, Palo Alto Medical Foundation, Palo Alto, CA, United States, Laboratory of Cardiovascular Physiology and Biophysics, Research Institute, Palo Alto Medical Foundation, 795 El Camino Real, Palo Alto, CA 94301-2302, United States (author)
Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States, Department of Mechanical Engineering, Stanford University, Stanford, CA, United StatesDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, United States (creator_code:org_t)

Related titles

In:American Journal of Physiology. Heart and Circulatory Physiology: American Physiological Society295:30363-61351522-1539

Internet link

Find in a library

American Journal of Physiology. Heart and Circulatory Physiology (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Krishnamurthy, G ...; Ennis, D.B.; Itoh, A.; Bothe, W.; Swanson, J.C.; Karlsson, Matts; show more...; Kuh, E.; Miller, D.C.; Ingels, Jr. N.B.; show less...

Articles in the publication: American Journal ...

By the university: Linköping University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se