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Sökning: (WFRF:(Stokes Mark Andrew)) > (2006-2009) > Neuronal pentraxins...

  • Bjartmar, Lisa,1966-Cleveland Clinic Foundation (författare)

Neuronal pentraxins mediate synaptic refinement in the developing visual system

  • Artikel/kapitelEngelska2006

Förlag, utgivningsår, omfång ...

  • 2006
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-51407
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-51407URI
  • https://doi.org/10.1523/JNEUROSCI.4212-05.2006DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Neuronal pentraxins (NPs) define a family of proteins that are homologous to C-reactive and acute-phase proteins in the immune system and have been hypothesized to be involved in activity-dependent synaptic plasticity. To investigate the role of NPs in vivo, we generated mice that lack one, two, or all three NPs. NP1/2 knock-out mice exhibited defects in the segregation of eye-specific retinal ganglion cell (RGC) projections to the dorsal lateral geniculate nucleus, a process that involves activity-dependent synapse formation and elimination. Retinas from mice lacking NP1 and NP2 had cholinergically driven waves of activity that occurred at a frequency similar to that of wild-type mice, but several other parameters of retinal activity were altered. RGCs cultured from these mice exhibited a significant delay in functional maturation of glutamatergic synapses. Other developmental processes, such as pathfinding of RGCs at the optic chiasm and hippocampal long-term potentiation and long-term depression, appeared normal in NP-deficient mice. These data indicate that NPs are necessary for early synaptic refinements in the mammalian retina and dorsal lateral geniculate nucleus. We speculate that NPs exert their effects through mechanisms that parallel the known role of short pentraxins outside the CNS.

Ämnesord och genrebeteckningar

  • retinogeniculate
  • neuronal pentraxins
  • synaptic plasticity
  • LTP
  • long-term potentiation
  • LTD
  • long-term depression
  • development
  • knock-out
  • retinal ganglion cell
  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Huberman, AndrewNeurobiology, Stanford University School of Medicine, Stanford, California 94305, USA (författare)
  • Ullian, ErikNeurobiology, Stanford University School of Medicine, Stanford, California 94305, USA (författare)
  • Rentería, René8Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143, USA (författare)
  • Liu, XiaoqinNeurosciences Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA (författare)
  • Xu, WeifengNeurobiology and Psychiatry, Stanford University School of Medicine, Stanford, California 94305, USA (författare)
  • Prezioso, JenniferNeurosciences and 2Ophthalmic Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA (författare)
  • Susman, MichaelNeurobiology, Stanford University School of Medicine, Stanford, California 94305, USA (författare)
  • Stellwagen, DavidNeurobiology and Psychiatry, Stanford University School of Medicine, Stanford, California 94305, USA (författare)
  • Stokes, CalebNeurobiology, Stanford University School of Medicine, Stanford, California 94305, USA (författare)
  • Cho, RichardDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA (författare)
  • Worley, PaulDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA (författare)
  • Malenka, RobertNeurobiology and Psychiatry, Stanford University School of Medicine, Stanford, California 94305, USA (författare)
  • Ball, SherryOphthalmic Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA/Research Service, Cleveland VA Medical Center, Cleveland, Ohio 44106, USA (författare)
  • Peachey, NealOphthalmic Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA/Research Service, Cleveland VA Medical Center, Cleveland, Ohio 44106, USA (författare)
  • Copenhagen, DavidDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California 94143, USA (författare)
  • Chapman, BarbaraCenter for Neuroscience, University of California, Davis, California 95616, USA (författare)
  • Nakamoto, MasaruNeurosciences Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA (författare)
  • Barres, BenNeurobiology, Stanford University School of Medicine, Stanford, California 94305, USA (författare)
  • Perin, MarkNeurosciences and 2Ophthalmic Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA (författare)
  • Cleveland Clinic FoundationNeurobiology, Stanford University School of Medicine, Stanford, California 94305, USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Neuroscience26:23, s. 6269-62810270-64741529-2401

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