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Maternal Age at Bir...
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Cardwell, Chris RQueens University Belfast
(author)
Maternal Age at Birth and Childhood Type 1 Diabetes: A Pooled Analysis of 30 Observational Studies
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2009-10-29
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American Diabetes Association,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-54157
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54157URI
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https://doi.org/10.2337/db09-1166DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVE-The aim if the study was to investigate whether children born to older mothers have an increased risk of type 1 diabetes by performing a pooled analysis of previous studies using individual patient data to adjust for recognized confounders. RESEARCH DESIGN AND METHODS-Relevant studies published before June 2009 were identified from MEDLINE, Web of Science, and EMBASE. Authors of studies were contacted and asked to provide individual patient data or conduct prespecified analyses. Risk estimates of type 1 diabetes by maternal age were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were used to derive combined odds ratios and to investigate heterogeneity among studies. RESULTS-Data were available for 5 cohort and 25 case-control studies, including 14,724 cases of type 1 diabetes. Overall, there was, on average, a 5% (95% CI 2-9) increase in childhood type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity among studies (heterogeneity I-2 = 70%). In studies with a low risk of bias, there was a more marked increase in diabetes odds of 10% per 5-year increase in maternal age. Adjustments for potential confounders little altered these estimates. CONCLUSIONS-There was evidence of a weak but significant linear increase in the risk of childhood type 1 diabetes across the range of maternal ages, but the magnitude of association varied between studies. A very small percentage of the increase in the incidence of childhood type 1 diabetes in recent years could be explained by increases in maternal age.
Subject headings and genre
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Stene, Lars CNorwegian Institute for Public Health
(author)
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Joner, GeirUniversity of Oslo
(author)
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Bulsara, Max KUniversity of Notre Dame
(author)
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Cinek, OndrejCharles University Prague
(author)
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Rosenbauer, JoachimUniversity of Dusseldorf
(author)
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Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29
(author)
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Jane, MireiaDepartment of Health, Public Health Div, Barcelona, Spain
(author)
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Svensson, JannetGlostrup University Hospital
(author)
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Goldacre, Michael JUniversity Oxford
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Waldhoer, ThomasMedical University of Vienna
(author)
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Jarosz-Chobot, PrzemyslawaMedical University of Silesia
(author)
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Gimeno, Suely G AUniversity Fed Sao Paulo
(author)
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Chuang, Lee-MingNational Taiwan University Hospital
(author)
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Parslow, Roger CUniversity of Leeds
(author)
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Wadsworth, Emma J KCardiff University
(author)
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Chetwynd, AmandaUniversity of Lancaster
(author)
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Pozzilli, PaoloUniversity Campus Biomed, Rome, Italy
(author)
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Brigis, GirtsRiga Stradins University
(author)
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Urbonaite, BroneKaunas University of Medicine
(author)
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Sipetic, SandraUniversity of Belgrade
(author)
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Schober, EdithMedical University of Vienna
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Devoti, GabrieleUniversity of Lecce
(author)
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Ionescu-Tirgoviste, ConstantinN Paulescu Institute Diabet
(author)
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de Beaufort, Carine EPediat Clin, Luxembourg
(author)
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Stoyanov, DenkaChildrens Diabet Centre, Sofia, Bulgaria
(author)
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Buschard, KarstenRigshosp, Bartholin Institute, DK-2100 Copenhagen, Denmark
(author)
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Patterson, Chris CQueens University Belfast
(author)
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Queens University BelfastNorwegian Institute for Public Health
(creator_code:org_t)
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In:DIABETES: American Diabetes Association59:2, s. 486-4940012-17971939-327X
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Linköping University