Search: WFRF:(Schober T.) >
Birthweight and the...
Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data
-
- Cardwell, C R (author)
- Queens University Belfast
-
- Stene, L C (author)
- Norwegian Institute Public Health
-
- Joner, G (author)
- Oslo University Hospital
-
show more...
-
- Davis, E A (author)
- University Western Australia
-
- Cinek, O (author)
- Charles University Prague
-
- Rosenbauer, J (author)
- University Dusseldorf
-
- Ludvigsson, Johnny (author)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
-
- Castell, C (author)
- Advisory Comm Diabet Catalonia, Barcelona, Spain
-
- Svensson, J (author)
- Glostrup University Hospital
-
- Goldacre, M J (author)
- University of Oxford
-
- Waldhoer, T (author)
- Medical University of Vienna
-
- Polanska, J (author)
- Silesian Technical University
-
- Gimeno, S G A (author)
- University Fed Sao Paulo
-
- Chuang, L-M (author)
- National Taiwan University Hospital
-
- Parslow, R C (author)
- University of Leeds
-
- Wadsworth, E J K (author)
- Cardiff University
-
- Chetwynd, A (author)
- University Lancaster
-
- Pozzilli, P (author)
- University Campus Biomed, Rome, Italy
-
- Brigis, G (author)
- Riga Stradins University
-
- Urbonaite, B (author)
- Kaunas University of Medicine
-
- Sipetic, S (author)
- University of Belgrade
-
- Schober, E (author)
- Medical University of Vienna
-
- Ionescu-Tirgoviste, C (author)
- N Paulescu Institute Diabet, Nutr and Metab Disease Clin, Bucharest, Romania
-
- de Beaufort, C E (author)
- Pediat Clin, Luxembourg
-
- Stoyanov, D (author)
- Childrens Diabet Centre, Sofia, Bulgaria
-
- Buschard, K (author)
- Rigshosp, Copenhagen
-
- Patterson, C C (author)
- Queens University Belfast
-
show less...
-
(creator_code:org_t)
- 2010-01-10
- 2010
- English.
-
In: DIABETOLOGIA. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 53:4, s. 641-651
- Related links:
-
https://link.springe...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- We investigated whether children who are heavier at birth have an increased risk of type 1 diabetes. Relevant studies published before February 2009 were identified from literature searches using MEDLINE, Web of Science and EMBASE. Authors of all studies containing relevant data were contacted and asked to provide individual patient data or conduct pre-specified analyses. Risk estimates of type 1 diabetes by category of birthweight were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were then used to derive combined ORs and investigate heterogeneity between studies. Data were available for 29 predominantly European studies (five cohort, 24 case-control studies), including 12,807 cases of type 1 diabetes. Overall, studies consistently demonstrated that children with birthweight from 3.5 to 4 kg had an increased risk of diabetes of 6% (OR 1.06 [95% CI 1.01-1.11]; p = 0.02) and children with birthweight over 4 kg had an increased risk of 10% (OR 1.10 [95% CI 1.04-1.19]; p = 0.003), compared with children weighing 3.0 to 3.5 kg at birth. This corresponded to a linear increase in diabetes risk of 3% per 500 g increase in birthweight (OR 1.03 [95% CI 1.00-1.06]; p = 0.03). Adjustments for potential confounders such as gestational age, maternal age, birth order, Caesarean section, breastfeeding and maternal diabetes had little effect on these findings. Children who are heavier at birth have a significant and consistent, but relatively small increase in risk of type 1 diabetes.
Keyword
- Birthweight
- Epidemiology
- Meta-analysis
- Risk factors
- Type 1 diabetes mellitus
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Cardwell, C R
-
Stene, L C
-
Joner, G
-
Davis, E A
-
Cinek, O
-
Rosenbauer, J
-
show more...
-
Ludvigsson, John ...
-
Castell, C
-
Svensson, J
-
Goldacre, M J
-
Waldhoer, T
-
Polanska, J
-
Gimeno, S G A
-
Chuang, L-M
-
Parslow, R C
-
Wadsworth, E J K
-
Chetwynd, A
-
Pozzilli, P
-
Brigis, G
-
Urbonaite, B
-
Sipetic, S
-
Schober, E
-
Ionescu-Tirgovis ...
-
de Beaufort, C E
-
Stoyanov, D
-
Buschard, K
-
Patterson, C C
-
show less...
- Articles in the publication
-
DIABETOLOGIA
- By the university
-
Linköping University