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Analysis of linkage...
Analysis of linkage and linkage disequilibrium for eight X-STR markers.
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- Tillmar, Andreas (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet,Linköping University
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- Mostad, Petter, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Mathematical Sciences, Chalmers University of Technology, and Mathematical Sciences Göteborg University, Göteborg, Sweden
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- Egeland, Thore (författare)
- Department of Medical Genetics, Ullevaal University Hospital, Oslo, Norway,Høgskolen i Oslo og Akershus (HiOA),Oslo and Akerhus University of Applied Sciences,Oslo universitetssykehus,Oslo University Hospital
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- Lindblom, Bertil (författare)
- Linköpings universitet,Rättsgenetik,Hälsouniversitetet,Linköping University
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- Holmlund, Gunilla (författare)
- National Board of Forensic Medicine, Department of Forensic Genetics and Forensic Toxicology, Linköping, Sweden,Linköpings universitet,Linköping University
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- Montelius, Kerstin (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet,Linköping University
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(creator_code:org_t)
- Elsevier, 2008
- 2008
- Engelska.
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Ingår i: Forensic science international. Genetics. - : Elsevier. - 1878-0326 .- 1872-4973. ; 3:1, s. 37-41
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://research.cha...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- X-chromosomal short tandem repeats (X-STR) have proven to be informative and useful in complex relationship testing. The main feature of X-STR markers, compared to autosomal forensic markers, is that all loci are located on the same chromosome. Thus, linkage and linkage disequilibrium may occur. The aim of this work was to study population genetic parameters of eight X-STR markers, located in four linkage groups. We present haplotype frequencies, based on 718 Swedish males, for the four linkage groups included in the Argus X-8 kit. Forensic efficiency parameters have been calculated as well as the allelic association between the tested markers for detection of linkage disequilibrium. To study the occurrences of recombination between the loci, both Swedish and Somali families were typed. A mathematical model for the estimation of recombination frequencies is presented and applied on the family samples. Our study showed that the tested markers all have highly informative forensic values and that there is a significant degree of linkage disequilibrium between the STR markers within the four linkage groups. Furthermore, based on the tested families, we also demonstrated that two of the linkage groups are partially linked. A consequence of these findings is that both linkage and linkage disequilibrium should be accounted for when producing likelihood ratios in relationship testing with X-STR markers.
Ämnesord
- NATURVETENSKAP -- Matematik -- Sannolikhetsteori och statistik (hsv//swe)
- NATURAL SCIENCES -- Mathematics -- Probability Theory and Statistics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Rättsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Forensic Science (hsv//eng)
Nyckelord
- X-chromosomal STR
- Linkage
- Linkage disequilibrium
- Recombination
- Likelihood ratios
- Sweden
- MEDICINE
- MEDICIN
- X-chromosomal STR Linkage Linkage disequilibrium Recombination Likelihood ratios Sweden
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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