Sökning: WFRF:(Dizdar Segrell Nil 1960 ) >
The Effect of Perip...
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Nord, MariaÖstergötlands Läns Landsting,Neurologiska kliniken
(författare)
The Effect of Peripheral Enzyme Inhibitors on Levodopa Concentrations in Blood and CSF
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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2010-01-13
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John Wiley & Sons,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-54855
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54855URI
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https://doi.org/10.1002/mds.22613DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Levodopa combined with a dopa-decarboxylase inhibitor, such as carbidopa. shifts the metabolism to the COMT pathway. Adding the peripheral acting COMT inhibitor entacapone provides improvement for patients with PD suffering from motor fluctuations. We studied the effects of the enzyme inhibitors entacapone and carbidopa on the levodopa concentrations in CSF and in blood. Five PD patients with wearing-off underwent lumbar drainage and intravenous microdialysis. Samples were taken 12 h daily for 3 days. Day I; intravenous levodopa was given, day 2; additional oral entacapone 200 mg tid, day 3; additional oral entacapone 200 mg bid and carbidopa 25 mg bid. Levodopa in CSF and in dialysates was analysed. The AUC for levodopa increased both in blood and CSF when additional entacapone was given alone and in combination with carbidopa. The C-max of levodopa in both CSF and blood increased significantly. Additional entacapone to levodopa therapy gives an increase of C-max in CSF and in blood. The increase is more evident when entacapone is combined with carbidopa.
Ämnesord och genrebeteckningar
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Parkinsons Disease
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levodopa
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continuous infusion
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COMT
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Zsigmond, PeterÖstergötlands Läns Landsting,Linköpings universitet,Neurokirurgi,Hälsouniversitetet,Neurokirurgiska kliniken US(Swepub:liu)petzs86
(författare)
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Kullman, AnitaLinköpings universitet,Klinisk kemi,Hälsouniversitetet(Swepub:liu)aniku95
(författare)
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Årstrand, KerstinLinköpings universitet,Klinisk kemi,Hälsouniversitetet(Swepub:liu)kerar67
(författare)
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Dizdar (Dizdar Segrell), Nil,1960-Östergötlands Läns Landsting,Neurologiska kliniken,Klinisk kemi(Swepub:liu)nildi39
(författare)
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Östergötlands Läns LandstingNeurologiska kliniken
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Movement Disorders: John Wiley & Sons25:3, s. 363-3670885-31851531-8257
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