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Molecular sampling ...
Molecular sampling of prostate cancer: a dilemma for predicting disease progression
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- Sboner, Andrea (författare)
- Department of Molecular Biophysics and Biochemistry, Yale University, New Haven CT, USA
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- Demichelis, Francesca (författare)
- Department of Pathology and LaboratoryMedicine, Weill Cornell Medical Center, New York, USA; Institute for Computational Biomedicine, Weill Cornell Medical Center, New York, USA
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- Calza, Stefano (författare)
- Karolinska Institutet,Karolinska Institute
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- Pawitan, Yudi (författare)
- Karolinska Institutet,Karolinska Institute
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- Setlur, Sunita R (författare)
- Department of Pathology, Brigham and Women's Hospital, Boston MA, USA
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- Hoshida, Yujin (författare)
- The Broad Institute of MIT and Harvard, Cambridge MA, USA; The Dana Farber Cancer Institute, Boston MA, USA
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- Perner, Sven (författare)
- Department of Pathology and LaboratoryMedicine, Weill Cornell Medical Center, New York, USA
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- Adami, Hans-Olov (författare)
- Karolinska Institutet,Karolinska Institute
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- Fall, Katja, 1971- (författare)
- Karolinska Institutet,Karolinska Institute
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- A Mucci, Lorelei (författare)
- Harvard University,Harvard Medical School, Boston MA, USA; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston MA, USA
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- Kantoff, Philip W (författare)
- Harvard Medical School, Boston MA, USA; The Dana Farber Cancer Institute, Boston MA, USA
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- Stampfer, Meir (författare)
- Harvard University,Harvard Medical School, Boston MA, USA; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston MA, USA
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- Andersson, Swen-Olof, 1949- (författare)
- Department of Urology, Örebro University Hospital, Örebro, Sweden
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- Varenhorst, Eberhard (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Urologi,Hälsouniversitetet,Urologiska kliniken i Östergötland,Department of Urology, Linköping University Hospital, Linköping, Sweden
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- Johansson, Jan-Erik (författare)
- Department of Urology, Örebro University Hospital, Örebro, Sweden
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- Gerstein, Mark B (författare)
- Department of Molecular Biophysics and Biochemistry, Yale University, New Haven CT, USA; Program in Computational Biology and Bioinformatics, Yale University, New Haven CT, USA; Department of Computer Science, Yale University, New Haven CT, USA
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- Golub, Todd R (författare)
- The Howard Hughes Medical Institute at The Broad Institute of MIT and Harvard, Cambridge MA, USA; The Broad Institute of MIT and Harvard, Cambridge MA, USA; The Dana Farber Cancer Institute, Boston MA, USA
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- Rubin, Mark A (författare)
- Medicine, Weill Cornell Medical Center, New York, USA; The Broad Institute of MIT and Harvard, Cambridge MA, USA
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- Andrén, Ove, 1963- (författare)
- Department of Urology, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2010-03-16
- 2010
- Engelska.
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Ingår i: BMC Medical Genomics. - London, United Kingdom : BioMed Central. - 1755-8794. ; 3:8
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://bmcmedgenomi...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Current prostate cancer prognostic models are based on pre-treatment prostate specific antigen (PSA) levels, biopsy Gleason score, and clinical staging but in practice are inadequate to accurately predict disease progression. Hence, we sought to develop a molecular panel for prostate cancer progression by reasoning that molecular profiles might further improve current clinical models. Methods: We analyzed a Swedish Watchful Waiting cohort with up to 30 years of clinical follow up using a novel method for gene expression profiling. This cDNA-mediated annealing, selection, ligation, and extension (DASL) method enabled the use of formalin-fixed paraffin-embedded transurethral resection of prostate (TURP) samples taken at the time of the initial diagnosis. We determined the expression profiles of 6100 genes for 281 men divided in two extreme groups: men who died of prostate cancer and men who survived more than 10 years without metastases (lethals and indolents, respectively). Several statistical and machine learning models using clinical and molecular features were evaluated for their ability to distinguish lethal from indolent cases. Results: Surprisingly, none of the predictive models using molecular profiles significantly improved over models using clinical variables only. Additional computational analysis confirmed that molecular heterogeneity within both the lethal and indolent classes is widespread in prostate cancer as compared to other types of tumors. Conclusions: The determination of the molecularly dominant tumor nodule may be limited by sampling at time of initial diagnosis, may not be present at time of initial diagnosis, or may occur as the disease progresses making the development of molecular biomarkers for prostate cancer progression challenging.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sboner, Andrea
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Demichelis, Fran ...
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Calza, Stefano
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Pawitan, Yudi
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Setlur, Sunita R
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Hoshida, Yujin
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visa fler...
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Perner, Sven
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Adami, Hans-Olov
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Fall, Katja, 197 ...
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A Mucci, Lorelei
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Kantoff, Philip ...
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Stampfer, Meir
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Andersson, Swen- ...
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Varenhorst, Eber ...
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Johansson, Jan-E ...
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Gerstein, Mark B
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Golub, Todd R
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Rubin, Mark A
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Andrén, Ove, 196 ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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BMC Medical Geno ...
- Av lärosätet
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Linköpings universitet
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Örebro universitet
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Karolinska Institutet