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Shaping up a lineag...
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Bryder, DavidLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
(författare)
Shaping up a lineage-lessons from B lymphopoesis
- Artikel/kapitelEngelska2010
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Elsevier Science B.V., Amsterdam.2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-56805
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-56805URI
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https://doi.org/10.1016/j.coi.2010.02.001DOI
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https://lup.lub.lu.se/record/1582508URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:for swepub-publicationtype
Anmärkningar
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Even though the development of B lymphoid cells from hematopoietic stem cells is one of the most carefully investigated models of cell differentiation in adult mammalians, a set of recent findings has to a large extent increased our understanding for how B lymphoid commitment is achieved. These include the identification of IKAROS, PU.1 and E2A as transcription factors responsible for lymphoid lineage priming in multipotent cells, as well as the identification of EBF1 dependent B lineage restricted progenitors among cells lacking expression of the classical B lineage markers CD19 or 8220. The insight that the B cell identity may be defined at an earlier stage then previously thought, allows for an increased understanding of B lymphoid development likely to unravel molecular mechanisms of high relevance also for other differentiation processes within as well as outside of the hematopoietic system.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sigvardsson, MikaelLund University,Lunds universitet,Linköpings universitet,Experimentell hematologi,Hälsouniversitetet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-msi
(författare)
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ImmunologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:CURRENT OPINION IN IMMUNOLOGY: Elsevier Science B.V., Amsterdam.22:2, s. 148-1530952-79151879-0372
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