Search: id:"swepub:oai:DiVA.org:liu-58406" >
Everolimus With Red...
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Gullestad, LarsUniversity of Oslo
(author)
Everolimus With Reduced Calcineurin Inhibitor in Thoracic Transplant Recipients With Renal Dysfunction: A Multicenter, Randomized Trial
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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Williams and Wilkins,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-58406
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-58406URI
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https://doi.org/10.1097/TP.0b013e3181cbac2dDOI
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https://lup.lub.lu.se/record/1541243URI
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https://gup.ub.gu.se/publication/120774URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background. The proliferation signal inhibitor everolimus offers the potential to reduce calcineurin inhibitor (CNI) exposure and alleviate CNI-related nephrotoxicity. Randomized trials in maintenance thoracic transplant patients are lacking. Methods. In a 12-month, open-labeled, multicenter study, maintenance thoracic transplant patients (glomerular filtration rate greater than= 20 mL/min/1.73m(2) and less than90 mL/min/1.73 m(2)) greater than1 year posttransplant were randomized to continue their current CNI-based immunosuppression or start everolimus with predefined CNI exposure reduction. Results. Two hundred eighty-two patients were randomized (140 everolimus, 142 controls; 190 heart, 92 lung transplants). From baseline to month 12, mean cyclosporine and tacrolimus trough levels in the everolimus cohort decreased by 57% and 56%, respectively. The primary endpoint, mean change in measured glomerular filtration rate from baseline to month 12, was 4.6 mL/min with everolimus and -0.5 mL/min in controls (Pless than0.0001). Everolimus-treated heart and lung transplant patients in the lowest tertile for time posttransplant exhibited mean increases of 7.8 mL/min and 4.9 mL/min, respectively. Biopsy-proven treated acute rejection occurred in six everolimus and four control heart transplant patients (P=0.54). In total, 138 everolimus patients (98.6%) and 127 control patients (89.4%) experienced one or more adverse event (P=0.002). Serious adverse events occurred in 66 everolimus patients (46.8%) and 44 controls (31.0%) (P=0.02). Conclusion. Introduction of everolimus with CNI reduction offers a significant improvement in renal function in maintenance heart and lung transplant recipients. The greatest benefit is observed in patients with a shorter time since transplantation.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Iversen, MartinRigshospital, Copenhagen
(author)
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Mortensen, Svend-AageUniversity of Oslo
(author)
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Eiskjaer, HansAarhus University Hospital,Capturo AS Stat Kjeller
(author)
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Riise, Gerdt C.,1956Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,Sahlgrens University Hospital(Swepub:gu)xriige
(author)
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Mared, LenaLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital(Swepub:lu)lung-lma
(author)
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Bjortuft, OysteinUniversity of Oslo
(author)
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Ekmehag, BjörnLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital(Swepub:lu)kard-bek
(author)
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Jansson, KjellÖstergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken(Swepub:liu)kjeja02
(author)
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Simonsen, SveinUniversity of Oslo
(author)
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Gude, EinarUniversity of Oslo
(author)
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Rundqvist, Bengt,1950Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine,University of Gothenburg(Swepub:gu)xrunbe
(author)
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E. Fagertun, HansCapturo AS Stat Kjeller
(author)
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Solbu, DagNovartis Norge AS
(author)
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Bergh, Claes-Håkan,1951Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine,University of Gothenburg(Swepub:gu)xbclan
(author)
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University of OsloRigshospital, Copenhagen
(creator_code:org_t)
Related titles
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In:Transplantation: Williams and Wilkins89:7, s. 864-8720041-13371534-6080
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Gullestad, Lars
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Iversen, Martin
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Mortensen, Svend ...
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Eiskjaer, Hans
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Riise, Gerdt C., ...
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Mared, Lena
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Bjortuft, Oystei ...
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Ekmehag, Björn
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Jansson, Kjell
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Simonsen, Svein
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Gude, Einar
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Rundqvist, Bengt ...
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E. Fagertun, Han ...
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Solbu, Dag
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Bergh, Claes-Håk ...
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Transplantation
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Linköping University
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Lund University
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University of Gothenburg