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Asymptomatic Norovi...
Asymptomatic Norovirus Infections in Nicaraguan Children and its Association With Viral Properties and Histo-blood Group Antigens
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- Bucardo, Filemon (author)
- University of Leon
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- Nordgren, Johan (author)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
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- Paniagua, Margarita (author)
- University of Leon
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- Mollby, Roland (author)
- Karolinska Institutet,Karolinska Institute
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- Svensson, Lennart (author)
- Linköpings universitet,Molekylär virologi,Hälsouniversitetet
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Carlsson, B (author)
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Kindberg, E (author)
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(creator_code:org_t)
- Williams and Wilkins, 2010
- 2010
- English.
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In: PEDIATRIC INFECTIOUS DISEASE JOURNAL. - : Williams and Wilkins. - 0891-3668 .- 1532-0987. ; 29:10, s. 934-939
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: It has been previously reported that histo-blood group antigens (HBGAs) and particularly secretor status provides protection against symptomatic norovirus infection, but it remains unclear to what extent this includes asymptomatic infections in children. Methods: To explore whether HBGAs or certain viral genotypes are associated with asymptomatic norovirus infections in a pediatric population in Nicaragua, we investigated 163 children andlt;= 5 years of age, without a recent history of diarrhea (andlt;= 10 days). Results: Asymptomatic norovirus infections were observed in 11.7% (19/163), with children andlt;= 6 months of age being most frequently infected (16%). Of the 19 norovirus-positive children, 4 (21%) and 10 (53%) were infected with genogroups GI and GII, respectively, and 4 children (21%) were infected with viruses of both genogroups. Most children had andgt;= 10(6) viral genomes per gram of feces. Nucleotide sequence analysis (15/19) revealed uncommon genotypes, such as, GII. 7 (n = 5) and GII. 2 (n = 3). An interesting observation was the low frequency of norovirus GII. 4 strains among the asymptomatic children. AB blood type, Lewis a (Lea(a+b-)) phenotype and nonsecretor genotype (se(428)se(428)) were not found among the asymptomatic children, but they occurred in population controls. Conclusions: Frequency of asymptomatic norovirus infections was similar to that observed in symptomatic children from Nicaragua. Norovirus GII. 2 and GII. 7 were frequently detected but the globally dominating GII. 4 was infrequent. Host genetic factors previously observed to be associated with protection against symptomatic norovirus infection were not found in this study.
Keyword
- norovirus
- asymptomatic
- host genetic factors
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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