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  • Butler, Christopher CCardiff University (author)

Treatment of acute cough/lower respiratory tract infection by antibiotic class and associated outcomes: a 13 European country observational study in primary care

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-09-18
  • Oxford University Press,2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-60888
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-60888URI
  • https://doi.org/10.1093/jac/dkq336DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Acute cough/lower respiratory tract infection (LRTI) is one of the commonest reasons for consulting and antibiotic prescribing. There are theoretical reasons why treatment with particular antibiotic classes may aid recovery more than others, but empirical, pragmatic evidence is lacking. We investigated whether treatment with a particular antibiotic class (amoxicillin) was more strongly associated with symptom score resolution and time to patients reporting recovery than each of eight other antibiotic classes or no antibiotic treatment for acute cough/LRTI. Clinicians recorded history, examination findings, symptom severity and antibiotic treatment for 3402 patients in a 13 country prospective observational study of adults presenting in 14 primary care research networks with acute cough/LRTI. 2714 patients completed a symptom score daily for up to 28 days and recorded the day on which they felt recovered. A three-level autoregressive moving average model (1,1) model investigated logged daily symptom scores to analyse symptom resolution. A two-level survival model analysed time to reported recovery. Clinical presentation was controlled for using clinician-recorded symptoms, sputum colour, temperature, age, co-morbidities, smoking status and duration of illness prior to consultation. Compared with amoxicillin, no antibiotic class (and no antibiotic treatment) was associated with clinically relevant improved symptom resolution (all coefficients in the range -0.02 to 0.01 and all P values greater than 0.12). No antibiotic class (and no antibiotic treatment) was associated with faster time to recovery than amoxicillin. Treatment by antibiotic class was not associated with symptom resolution or time to recovery in adults presenting to primary care with acute cough/LRTI.

Subject headings and genre

  • antibiotic resistance
  • patient outcome
  • clinical epidemiology
  • antibiotic choice
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kelly, Mark JCardiff University (author)
  • Goossens, HermanUniversity of Antwerp (author)
  • Verheij, TheoUniversity Medical Centre Utrecht (author)
  • Little, PaulUniversity of Southampton (author)
  • Melbye, HasseUniversity of Tromso (author)
  • Torres, AntoniUniversity of Barcelona (author)
  • Mölstad, SigvardLinköpings universitet,Allmänmedicin,Hälsouniversitetet(Swepub:liu)sigmo13 (author)
  • Godycki-Cwirko, MaciekMedical University Lodz (author)
  • Almirall, JordiHospital Mataro (author)
  • Blasi, FrancescoUniversity of Milan (author)
  • Schaberg, TomDeaconess Hospital Rotenburg (author)
  • Edwards, PeterEly Bridge Surg, Cardiff (author)
  • Rautakorpi, Ulla-MaijaTampere Off (author)
  • Hupkova, HelenaComenius University (author)
  • Wood, JosephCardiff University (author)
  • Nuttall, JacquiCardiff University (author)
  • Coenen, SamuelUniversity of Antwerp (author)
  • Cardiff UniversityUniversity of Antwerp (creator_code:org_t)

Related titles

  • In:JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY: Oxford University Press65:11, s. 2472-24780305-74531460-2091

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