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Assaying cardiac bi...
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Andersson, HenrikLinköpings universitet,Teknisk biologi,Tekniska fakulteten
(author)
Assaying cardiac biomarkers for toxicity testing using biosensing and cardiomyocytes derived from human embryonic stem cells
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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Elsevier Science B.V., Amsterdam.2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-62153
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-62153URI
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https://doi.org/10.1016/j.jbiotec.2010.06.023DOI
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https://gup.ub.gu.se/publication/130205URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Human embryonic stem cell (hESC) derived cardiomyocytes are in the present study being used for testing drug-induced cardiotoxicity in a biosensor set-up. The design of an in vitro testing alternative provides a novel opportunity to surpass previous methods based on rodent cells or cell lines due to its significantly higher toxicological relevance. In this report we demonstrate how hESC-derived cardiomyocytes release detectable levels of two clinically decisive cardiac biomarkers, cardiac troponin T and fatty acid binding protein 3, when the cardiac cells are exposed to the well-known cardioactive drug compound. doxorubicin. The release is monitored by the immuno-biosensor technique surface plasmon resonance, particularly appropriate due to its capacity for parallel and high-throughput analysis in complex media.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Steel, DaniellaCellartis AB, Gothenburg, Sweden
(author)
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Asp, Julia,1973Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,University of Gothenburg(Swepub:gu)xaspjd
(author)
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Dahlenborg, KerstinLinköpings universitet,Teknisk biologi,Tekniska högskolan
(author)
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Jonsson, Marianne,1962Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,University of Gothenburg(Swepub:gu)xjmare
(author)
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Jeppsson, Anders,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrens University Hospital(Swepub:gu)xjepan
(author)
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Lindahl, Anders,1954Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,University of Gothenburg(Swepub:gu)xlandy
(author)
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Kågedal, BertilÖstergötlands Läns Landsting,Linköpings universitet,Klinisk kemi,Hälsouniversitetet(Swepub:liu)berka70
(author)
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Sartipy, PeterCellartis AB, Gothenburg, Sweden
(author)
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Mandenius, Carl-FredrikLinköpings universitet,Teknisk biologi,Tekniska högskolan(Swepub:liu)carma16
(author)
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Linköpings universitetTeknisk biologi
(creator_code:org_t)
Related titles
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In:JOURNAL OF BIOTECHNOLOGY: Elsevier Science B.V., Amsterdam.150:1, s. 175-1810168-16561873-4863
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Andersson, Henri ...
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Steel, Daniella
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Asp, Julia, 1973
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Dahlenborg, Kers ...
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Jonsson, Mariann ...
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Jeppsson, Anders ...
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Lindahl, Anders, ...
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Kågedal, Bertil
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Sartipy, Peter
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Mandenius, Carl- ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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JOURNAL OF BIOTE ...
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Linköping University
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University of Gothenburg