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Search: L773:0168 1656 OR L773:1873 4863 > (2010-2014) > Assaying cardiac bi...

  • Andersson, HenrikLinköpings universitet,Teknisk biologi,Tekniska fakulteten (author)

Assaying cardiac biomarkers for toxicity testing using biosensing and cardiomyocytes derived from human embryonic stem cells

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • Elsevier Science B.V., Amsterdam.2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-62153
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-62153URI
  • https://doi.org/10.1016/j.jbiotec.2010.06.023DOI
  • https://gup.ub.gu.se/publication/130205URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Human embryonic stem cell (hESC) derived cardiomyocytes are in the present study being used for testing drug-induced cardiotoxicity in a biosensor set-up. The design of an in vitro testing alternative provides a novel opportunity to surpass previous methods based on rodent cells or cell lines due to its significantly higher toxicological relevance. In this report we demonstrate how hESC-derived cardiomyocytes release detectable levels of two clinically decisive cardiac biomarkers, cardiac troponin T and fatty acid binding protein 3, when the cardiac cells are exposed to the well-known cardioactive drug compound. doxorubicin. The release is monitored by the immuno-biosensor technique surface plasmon resonance, particularly appropriate due to its capacity for parallel and high-throughput analysis in complex media.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Steel, DaniellaCellartis AB, Gothenburg, Sweden (author)
  • Asp, Julia,1973Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,University of Gothenburg(Swepub:gu)xaspjd (author)
  • Dahlenborg, KerstinLinköpings universitet,Teknisk biologi,Tekniska högskolan (author)
  • Jonsson, Marianne,1962Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,University of Gothenburg(Swepub:gu)xjmare (author)
  • Jeppsson, Anders,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrens University Hospital(Swepub:gu)xjepan (author)
  • Lindahl, Anders,1954Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,University of Gothenburg(Swepub:gu)xlandy (author)
  • Kågedal, BertilÖstergötlands Läns Landsting,Linköpings universitet,Klinisk kemi,Hälsouniversitetet(Swepub:liu)berka70 (author)
  • Sartipy, PeterCellartis AB, Gothenburg, Sweden (author)
  • Mandenius, Carl-FredrikLinköpings universitet,Teknisk biologi,Tekniska högskolan(Swepub:liu)carma16 (author)
  • Linköpings universitetTeknisk biologi (creator_code:org_t)

Related titles

  • In:JOURNAL OF BIOTECHNOLOGY: Elsevier Science B.V., Amsterdam.150:1, s. 175-1810168-16561873-4863

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