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  • Coenen, Marieke J HRadboud University Nijmegen (author)

Genetic Variants in Toll-Like Receptors Are Not Associated with Rheumatoid Arthritis Susceptibility or Anti-Tumour Necrosis Factor Treatment Outcome

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-12-15
  • Public Library of Science (PLoS),2010
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-64236
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-64236URI
  • https://doi.org/10.1371/journal.pone.0014326DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:121756005URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Original Publication: Marieke J H Coenen, Christian Enevold, Pilar Barrera, Mascha M V A P Schijvenaars, Erik J M Toonen, Hans Scheffer, Leonid Padyukov, Alf Kastbom, Lars Klareskog, Anne Barton, Wietske Kievit, Tim L Jansen, Dorine Swinkels, Piet L C M van Riel, Barbara Franke, Klaus Bendtzen and Timothy R D J Radstake, Genetic Variants in Toll-Like Receptors Are Not Associated with Rheumatoid Arthritis Susceptibility or Anti-Tumour Necrosis Factor Treatment Outcome, 2010, PLOS ONE, (5), 12. http://dx.doi.org/10.1371/journal.pone.0014326 Licensee: Public Library of Science (PLoS) http://www.plos.org/
  • Background: Several studies point to a role of Toll-like receptors (TLRs) in the development of rheumatoid arthritis (RA). We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication. Methodology and Principal Findings: 22 single nucleotide polymorphisms (SNPs) in seven TLR genes were genotyped in a Dutch cohort consisting of 378 RA patients and 294 controls. Significantly associated variants were investigated in replication cohorts from The Netherlands, United Kingdom and Sweden (2877 RA patients and 2025 controls). 182 of the Dutch patients were treated with anti-TNF medication. Using these patients and a replication cohort (269 Swedish patients) we analysed if genetic variants in TLR genes were associated with anti-TNF outcome. In the discovery phase of the study we found a significant association of SNPs rs2072493 in TLR5 and rs3853839 in TLR7 with RA disease susceptibility. Meta-analysis of discovery and replication cohorts did not confirm these findings. SNP rs2072493 in TLR5 was associated with anti-TNF outcome in the Dutch but not in the Swedish population. Conclusion: We conclude that genetic variants in TLRs do not play a major role in susceptibility for developing RA nor in anti-TNF treatment outcome in a Caucasian population.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Enevold, ChristianUniversity of Copenhagen Hospital (author)
  • Barrera, PilarRadboud University Nijmegen (author)
  • Schijvenaars, Mascha M V A PRadboud University Nijmegen (author)
  • J M Toonen, ErikRadboud University Nijmegen (author)
  • Scheffer, HansRadboud University Nijmegen (author)
  • Padyukov, LeonidKarolinska Institutet,Karolinska Institute (author)
  • Kastbom, AlfÖstergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Länskliniken för Reumatologi i Östergötland(Swepub:liu)alfka05 (author)
  • Klareskog, LarsKarolinska Institutet,Karolinska Institute (author)
  • Barton, AnneUniversity of Manchester (author)
  • Kievit, WietskeZiekenhuis Gelderse Vallei (author)
  • Jansen, Tim LMedical Centre Leeuwarden (author)
  • Swinkels, DorineRadboud University Nijmegen (author)
  • van Riel, Piet L C MRadboud University Nijmegen (author)
  • Franke, BarbaraRadboud University Nijmegen (author)
  • Bendtzen, KlausUniversity of Copenhagen Hospital (author)
  • Radstake, Timothy R D JRadboud University Nijmegen (author)
  • Rood, MJ (author)
  • Radboud University NijmegenUniversity of Copenhagen Hospital (creator_code:org_t)

Related titles

  • In:PLOS ONE: Public Library of Science (PLoS)5:121932-6203

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