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Prospective Diary E...
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Walter, Susanna AÖstergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
(author)
Prospective Diary Evaluation of Unexplained Abdominal Pain and Bowel Dysfunction : A Population-Based Colonoscopy Study
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2010-11-10
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Springer,2011
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LIBRIS-ID:oai:DiVA.org:liu-64317
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-64317URI
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https://doi.org/10.1007/s10620-010-1468-yDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:122470448URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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INTRODUCTION: Diagnostic criteria for irritable bowel syndrome (IBS) have not been validated by prospective symptom diary. We investigated the bowel patterns in community subjects with and without non-organic abdominal pain, and compared the symptoms with subjects fulfilling the Rome II criteria (IBS). METHODS: From the Swedish population register, a random sample completed an abdominal symptom questionnaire. Responders were subsequently invited for a clinical evaluation and offered a colonoscopy regardless of whether they had abdominal symptoms or not. A total of 268 subjects underwent colonoscopy, clinical evaluation by gastroenterologist, laboratory investigations, and completed the Rome questionnaire and prospective gastrointestinal (GI) symptom diaries for 1 week. Twenty-three subjects of 268 were excluded due to organic GI disease. RESULTS: Subjects recorded 2,194 bowel movements and 370 abdominal pain episodes on 1,504 days. Subjects with pain in the diary (n = 81) had higher stool frequency (P = 0.01), more urgency (P = 0.0002), feelings of incomplete evacuation (P = 0.0002), nausea (P = 0.0009), and abdominal bloating (P = 0.0005) than subjects without pain (n = 151). Twenty-eight subjects (12%) fulfilled the Rome II criteria for IBS. Together, they had 96 pain episodes but only 4% were improved by defecation; 29% of the pain episodes started or worsened after a meal. Subjects with IBS and other subjects with non-organic abdominal pain (n = 64) exhibited no differences in terms of the proportions of pain episodes improved by defecation, bloating, stool frequency, consistency, or defecatory symptoms. CONCLUSIONS: Current criteria for IBS that rely on recall of the relationship between abdominal pain and bowel disturbance may overcall this association when measured prospectively.
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Kjellström, LarsDepartment of Gastroenterology, Sabbatsbergs Hospital, Karolinska Institutet, Stockholm, Sweden
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Talley, Nicholas JFaculty of Health, University of Newcastle, Newcastle, NSW, Australia
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Andreasson, Anna NixonKarolinska Institutet,Center for Family and Community Medicine, Karolinska Institutet, Stockholm, Sweden
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Nyhlin, HenryDepartment of Gastroenterology, Karolinska Institutet, Stockholm, Sweden
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Agréus, LarsKarolinska Institutet,Center for Family and Community Medicine, Karolinska Institutet, Stockholm, Sweden
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Linköpings universitetGastroenterologi och hepatologi
(creator_code:org_t)
Related titles
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In:Digestive Diseases and Sciences: Springer56:5, s. 1444-14510163-21161573-2568
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