SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Sorri Martti)
 

Sökning: WFRF:(Sorri Martti) > A genome-wide analy...

  • Huyghe, Jeroen RDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium (författare)

A genome-wide analysis of population structure in the Finnish Saami with implications for genetic association studies

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • 2010-12-08
  • Nature Publishing Group,2011
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-66138
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66138URI
  • https://doi.org/10.1038/ejhg.2010.179DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63459URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agercies:European Community QLRT-2001-00331 University of Antwerp  Research Foundation - Flanders (FWO) G.0163.09 State of Arizona 
  • The understanding of patterns of genetic variation within and among human populations is a prerequisite for successful genetic association mapping studies of complex diseases and traits. Some populations are more favorable for association mapping studies than others. The Saami from northern Scandinavia and the Kola Peninsula represent a population isolate that, among European populations, has been less extensively sampled, despite some early interest for association mapping studies. In this paper, we report the results of a first genome-wide SNP-based study of genetic population structure in the Finnish Saami. Using data from the HapMap and the human genome diversity project (HGDP-CEPH) and recently developed statistical methods, we studied individual genetic ancestry. We quantified genetic differentiation between the Saami population and the HGDP-CEPH populations by calculating pair-wise F-ST statistics and by characterizing identity-by-state sharing for pair-wise population comparisons. This study affirms an east Asian contribution to the predominantly European-derived Saami gene pool. Using model-based individual ancestry analysis, the median estimated percentage of the genome with east Asian ancestry was 6% (first and third quartiles: 5 and 8%, respectively). We found that genetic similarity between population pairs roughly correlated with geographic distance. Among the European HGDP-CEPH populations, F-ST was smallest for the comparison with the Russians (F-ST=0.0098), and estimates for the other population comparisons ranged from 0.0129 to 0.0263. Our analysis also revealed fine-scale substructure within the Finnish Saami and warns against the confounding effects of both hidden population structure and undocumented relatedness in genetic association studies of isolated populations.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Fransen, ErikDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUA Statistics Center, University of Antwerp, Antwerp, Belgium (författare)
  • Hannula, SamuliInstitute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Oulu, Finland (författare)
  • Van Laer, LutDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium (författare)
  • Van Eyken, ElsDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium (författare)
  • Mäki-Torkko, ElinaÖrebro universitet,Linköpings universitet,Teknisk audiologi,Hälsouniversitetet,Institutionen för medicinska vetenskaper,Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Oulu, Finland; Department of Clinical and Experimental Medicine/Technical Audiology, Linköping University, Linköping, Sweden(Swepub:oru)emo (författare)
  • Aikio, PekkaThule Institute, University of Oulu, Oulu, Finland (författare)
  • Sorri, MarttiInstitute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Oulu, Finland (författare)
  • Huentelman, Matthew JTranslat Genom Research Institute, Phoenix,Neurogenomics Division, Translational Genomics Research Institute, Phoenix AZ, USA (författare)
  • Van Camp, GuyDepartment of Medical Genetics, University of Antwerp,Antwerp, Belgium (författare)
  • Department of Medical Genetics, University of Antwerp, Antwerp, BelgiumDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUA Statistics Center, University of Antwerp, Antwerp, Belgium (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:EUROPEAN JOURNAL OF HUMAN GENETICS: Nature Publishing Group19:3, s. 347-3521018-48131476-5438

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy