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Sökning: WFRF:(Hedelin Maria) > Dietary Phytoestrog...

  • Hedelin, Maria,1964Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Folkhalsan Research Centre (författare)

Dietary Phytoestrogens and the Risk of Ovarian Cancer in the Womens Lifestyle and Health Cohort Study

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • American Association for Cancer Research Inc,2011
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-66145
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66145URI
  • https://doi.org/10.1158/1055-9965.EPI-10-0752DOI
  • https://gup.ub.gu.se/publication/135336URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:121927124URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Dietary intake of phytoestrogens has been inversely associated to hormone-dependent cancers, such as prostate and breast cancers. Few studies have investigated the association between ovarian cancer and intake of phytoestrogens. We evaluated the associations between intake of phytoestrogens (isoflavonoids/lignans/coumestrol) and fiber (vegetable/cereal) and risk of ovarian cancer. Methods: In 1991-1992 a prospective population-based cohort study among Swedish women was conducted, including 47,140 women with complete dietary questionnaire data. During follow-up until December 2007, 163 women developed invasive (n = 117) and borderline (n = 46) ovarian cancers. The median follow-up time was 16 years and total person year was 747,178. Cox proportional hazards models were conducted to estimate multivariate risk ratios, 95% CI for associations with risk of ovarian cancer. Results: We found no association between intake of phytoestrogens or fiber and overall ovarian cancer risk. In addition, we found no statistically significant association between intake of specific food items rich in phytoestrogens (berries, nuts, beans/soy, and crisp or whole-grain bread) and ovarian cancer risk overall. Fiber and coumestrol was inversely associated with borderline ovarian cancer, but not with invasive ovarian cancer. Conclusions: We found no association between intake of phytoestrogens or fiber and overall ovarian cancer risk. Impact: Phytoestrogens do not play a major etiologic role in ovarian cancer, at least among women in this Swedish cohort with low bean/soy intake. However, our results of a difference in the effect of fiber or coumestrol between invasive and borderline ovarian cancer need to be evaluated in larger studies.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Löf, MarieKarolinska Institutet,Linköpings universitet,Näringslära,Hälsouniversitetet,Karolinska Institute(Swepub:liu)marlo59 (författare)
  • Andersson, Therese M -LKarolinska Institute (författare)
  • Adlercreutz, HermanUniversity of Helsinki (författare)
  • Weiderpass, ElisabeteKarolinska Institutet,Karolinska Institute (författare)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för onkologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:CANCER EPIDEMIOLOGY BIOMARKERS and PREVENTION: American Association for Cancer Research Inc20:2, s. 308-317:20, s. 308-3171055-9965
  • Ingår i:Cancer epidemiology, biomarkers & prevention: American Association for Cancer Research Inc20:2, s. 308-317:20, s. 308-3171538-7755

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