Search: (AMNE:(MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Anestesi och intensivvård)) srt2:(2010-2014) >
Dynamics of leukocy...
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Johansson, JoakimLinköpings universitet,Hälsouniversitetet,Institutionen för klinisk och experimentell medicin,Department of Perioperative Medicine, Faculty of Health Sciences, Linköping University Hospital, Linköping, Sweden
(author)
Dynamics of leukocyte receptors after severe burns: An exploratory study
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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Oxford :Elsevier Science B.V., Amsterdam.2011
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-67169
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-67169URI
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https://doi.org/10.1016/j.burns.2010.08.015DOI
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https://lup.lub.lu.se/record/1936331URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-124887URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Original Publication: Joakim Johansson, Florence Sjögren, Mikael Bodelsson and Folke Sjöberg, Dynamics of leukocyte receptors after severe burns: An exploratory study, 2011, BURNS, (37), 2, 227-233. http://dx.doi.org/10.1016/j.burns.2010.08.015 Copyright: Elsevier Science B.V., Amsterdam. http://www.elsevier.com/
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Background: Patients with burns are susceptible to organ failure, and there is indirect evidence that leukocytes may contribute to this process. They may change the expression of cell-surface receptors after certain stimuli, for example, the burn. We therefore aimed to assess the changes induced by the burn in the expression of leukocyte cell-surface receptors CD11b, CD14, CD16, and CD62L on the surface of PMNs and monocytes. We also wanted to examine the dynamics of this activation during the first week after the burn, and to relate it to the size of the injury. Methods: Ten patients with burns of andgt;15% (TBSA) were included in the study. Blood samples were collected on arrival and every consecutive morning during the first week. Healthy volunteers acted as controls. Results: PMN CD11b expression was increased. The extent of PMN CD11b expression correlated negatively to the size of the full thickness burn. Monocyte CD14 expression increased initially but there was no relation to the size of the burn. PMN CD16 expression decreased initially during the first days and the decrease was related to burn size. CD62L did not vary depending on the burn in either PMN or monocytes during the first week after the burn. Conclusion: This study showed that specific receptors on the surface of leukocytes (PMN CD11b, monocyte CD14 and PMN CD16) are affected by the burn. Expression of PMN CD11b and CD16 are related to burn size. Burn-induced effects on the expression of PMN receptors, such as PMN CD11b and CD16, may contribute to burn-induced infection susceptibility.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Sjögren, FlorenceÖstergötlands Läns Landsting,Linköpings universitet,Dermatologi och venerologi,Hälsouniversitetet,Hudkliniken i Östergötland(Swepub:liu)flosj73
(author)
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Bodelsson, MikaelLund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)anes-mbo
(author)
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Sjöberg, FolkeÖstergötlands Läns Landsting,Linköpings universitet,Brännskadevård,Hälsouniversitetet,Hand- och plastikkirurgiska kliniken US,Anestesi- och operationkliniken US(Swepub:liu)folsj94
(author)
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Linköpings universitetHälsouniversitetet
(creator_code:org_t)
Related titles
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In:BURNSOxford : Elsevier Science B.V., Amsterdam.37:2, s. 227-2330305-41791879-1409
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