Difficulties and possibilities with thiopurine therapy in inflammatory bowel disease-Proceedings of the first Thiopurine Task Force meeting

van Asseldonk, Dirk PVrije University Amsterdam Medical Centre, Amsterdam, The Netherlands (författare)

Background: Thiopurines, such as azathioprine and mercaptopurine, are of pivotal importance in the treatment of inflammatory bowel disease. Although these drugs have been used for several decades, still many questions remain unanswered. Aim: To provide an overview of clinically and scientifically challenging topics concerning thiopurine therapy in inflammatory bowel disease treatment. Methods: The first meeting of the Thiopurine Task Force Interest Group was held during the 2009 United European Gastroenterology Week in London (GASTRO2009). The topics of this meeting were of particular clinical and scientific interest. Additional literature was identified by performing a Pubmed search using the search terms inflammatory bowel disease, azathioprine, 6-mercaptopurine and thioguanine. Results: The following topics were discussed: therapeutic drug monitoring; the synergy of thiopurines with aminosalicylates and allopurinol; serious adverse events such as opportunistic infections, hepatotoxicity, carcinogenicity and pancreatitis; prolongation of thiopurines during clinical remission; indications for thiopurines in the postoperative setting; and the potential use of thioguanine. Specific interesting and clinically relevant topics for potential future research are provided. Conclusions: Thiopurines remain central to inflammatory bowel disease treatment, although future studies are required to substantiate a more personalised medicine approach to their use.

Sanderson, JeremyGuys and St Thomas Hospital, London, UK (författare)
de Boer, Nanne K HVrije University Amsterdam Medical Centre, Amsterdam, The Netherlands (författare)
Sparrow, Miles PAlfred Hospital, Melbourne, Australia (författare)
Lemann, MarcHôpital Saint Louis, Paris, France (författare)
Ansari, AzharEast Surrey Hospital, Red Hill, UK (författare)
Almer, SvenÖstergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US(Swepub:liu)sveal38 (författare)
Florin, Timothy H JUniversity of Queensland, Brisbane, Australia (författare)
Gearry, Richard BUniversity of Otago, Christchurch, New Zealand (författare)
Mulder, Chris JVrije University Amsterdam Medical Centre, Amsterdam, The Netherlands (författare)
Mantzaris, GerassimosEvangelisms Hospital, Athens, Greece (författare)
van Bodegraven, Ad AVrije University Amsterdam Medical Centre, Amsterdam, The Netherlands (författare)
Vrije University Amsterdam Medical Centre, Amsterdam, The NetherlandsGuys and St Thomas Hospital, London, UK (creator_code:org_t)

Ingår i:DIGESTIVE AND LIVER DISEASE: Elsevier Science B.V., Amsterdam43:4, s. 270-2761590-8658

Av författaren/redakt...: van Asseldonk, D ...; Sanderson, Jerem ...; de Boer, Nanne K ...; Sparrow, Miles P; Lemann, Marc; Ansari, Azhar; visa fler...; Almer, Sven; Florin, Timothy ...; Gearry, Richard ...; Mulder, Chris J; Mantzaris, Geras ...; van Bodegraven, ...; visa färre...

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