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Lack of Prognostic ...
Lack of Prognostic Value of Type D Personality for Mortality in a Large Sample of Heart Failure Patients
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- Coyne, James C (författare)
- University of Groningen
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- Jaarsma, Tiny (författare)
- Linköpings universitet,Hälsa, Aktivitet, Vård (HAV),Hälsouniversitetet
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- Luttik, Marie-Louise (författare)
- University of Groningen
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- van Sonderen, Eric (författare)
- University of Groningen
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- van Veldhuisen, Dirk J (författare)
- University of Groningen
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- Sanderman, Robbert (författare)
- University of Groningen
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(creator_code:org_t)
- Lippincott, Williams and Wilkins, 2011
- 2011
- Engelska.
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Ingår i: Psychosomatic Medicine. - : Lippincott, Williams and Wilkins. - 0033-3174 .- 1534-7796. ; 73:7, s. 557-562
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Type D personality has been proposed as a prognostic indicator for mortality in cardiovascular disease. Most research examining this construct originates from one research group, and it is critical that the predictive value of Type D personality for adverse outcomes is independently cross-validated. This study examined its prognostic value in heart failure, relative to B-type natriuretic peptide (BNP) and depressive symptoms. Methods: We studied 706 patients with complete BNP, depressive symptom, and Type D personality and mortality data from 958 patients with heart failure enrolled after hospitalization for a multisite study of a disease management program. Multivariable models were adjusted for BNP and depression. Results: At 18 months, there were 192 deaths (27.2%). No evidence was found for a prognostic value of Type D personality in the unadjusted model (hazard ratio [HR] = 0.893, 95% confidence interval [CI] = 0.582-1.370). In contrast, BNP was significantly predictive of mortality (HR = 1.588, 95% CI = 1.391-1.812), whereas depression was not (HR = 1.011, 95% CI = 0.998-1.024). Type D was also not predictive in covariate-adjusted models (HR = 0.779, 95% CI = 0.489-1.242). Similar results were obtained when analyzing Type D as the interaction between continuous z scores of its two components, negative affectivity and social inhibition (p = .144). Conclusions: In the largest study to date, Type D does not predict mortality. Future research should construe Type D as the interaction of continuous negative affectivity and social inhibition z scores, rather than as a typology, and consider analyses replacing negative affectivity with depression.
Nyckelord
- Type D personality
- heart failure
- survival
- B-type natriuretic peptide
- depression
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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