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Vitamin D status an...
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Liu, Licette C YUniversity of Groningen
(författare)
Vitamin D status and outcomes in heart failure patients
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2014-02-18
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Wiley,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-71507
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71507URI
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https://doi.org/10.1093/eurjhf/hfr032DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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AIMS: Vitamin D status has been implicated in the pathophysiology of heart failure (HF). The aims of this study were to determine whether a low vitamin D status is associated with prognosis in HF and whether activation of the renin-angiotensin system (RAS) and inflammatory markers could explain this potential association. METHODS AND RESULTS: We measured 25-hydroxy-vitamin D (25(OH)D), plasma renin activity (PRA), interleukin-6 (IL-6), C-reactive protein (CRP), and the incidence of death or HF rehospitalization in 548 patients with HF. Median age was 74 (64-80) years, left ventricular ejection fraction was 30% (23-42), and mean follow-up was 18 months. Low 25(OH)D levels were associated with female gender (P< 0.001), higher age (P= 0.002), and higher N-terminal pro-brain natriuretic peptide (NT-proBNP) levels (P< 0.001). Multivariable linear regression analysis showed that PRA (P= 0.048), and CRP levels (P= 0.006) were independent predictors of 25(OH)D levels. During follow-up, 155 patients died and 142 patients were rehospitalized. Kaplan-Meier analysis showed that lower 25(OH)D concentration was associated with an increased risk for the combined endpoint (all-cause mortality and HF rehospitalization; log rank test P= 0.045) and increased risk for all-cause mortality (log rank test P= 0.014). After adjustment in a multivariable Cox regression analysis, low 25(OH)D concentration remained independently associated with an increased risk for the combined endpoint [hazard ratio (HR) 1.09 per 10 nmol/L decrease; 95% confidence interval (CI) 1.00-1.16; P= 0.040] and all-cause mortality (HR 1.10 per 10 nmol/L decrease; 95% CI 1.00-1.22; P= 0.049). CONCLUSION: A low 25(OH)D concentration is associated with a poor prognosis in HF patients. Activation of the RAS and inflammation may confer the adverse effects of low vitamin D levels.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Voors, Adriaan AUniversity of Groningen
(författare)
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van Veldhuisen, Dirk JUniversity of Groningen
(författare)
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van der Veer, EvelineUniversity of Groningen
(författare)
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Belonje, Anne MUniversity of Groningen
(författare)
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Szymanski, Mariusz KUniversity of Groningen
(författare)
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Silljé, Herman H WUniversity of Groningen
(författare)
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van Gilst, Wiek HUniversity of Groningen
(författare)
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Jaarsma, TinyLinköpings universitet,Hälsa, Aktivitet, Vård (HAV),Hälsouniversitetet(Swepub:liu)tinja77
(författare)
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de Boer, Rudolf AUniversity of Groningen
(författare)
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University of GroningenHälsa, Aktivitet, Vård (HAV)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Heart Failure: Wiley13:6, s. 619-6251388-98421879-0844
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Liu, Licette C Y
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Voors, Adriaan A
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van Veldhuisen, ...
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van der Veer, Ev ...
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Belonje, Anne M
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Szymanski, Mariu ...
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Silljé, Herman H ...
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van Gilst, Wiek ...
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Jaarsma, Tiny
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de Boer, Rudolf ...
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Linköpings universitet