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Predictive value of...
Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction
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- de Boer, Rudolf A (författare)
- University of Groningen
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- Lok, Dirk J A (författare)
- Deventer Hospital, The Netherlands
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- Jaarsma, Tiny (författare)
- Linköpings universitet,Hälsa, Aktivitet, Vård (HAV),Hälsouniversitetet
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- van der Meer, Peter (författare)
- University of Groningen
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- Voors, Adriaan A (författare)
- University of Groningen
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- Hillege, Hans L (författare)
- University of Groningen
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- van Veldhuisen, Dirk J (författare)
- University of Groningen
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(creator_code:org_t)
- 2010-12-28
- 2011
- Engelska.
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Ingår i: Annals of Medicine. - : Informa UK Limited. - 0785-3890 .- 1365-2060. ; 43:1, s. 60-68
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- AIMS: galectin-3 is an emerging biomarker which has been studied in relatively small heart failure (HF) cohorts with predominantly systolic HF. We studied the prognostic value of base-line galectin-3 in a large HF cohort, with preserved and reduced left ventricular ejection fraction (LVEF), and compared this to other biomarkers. METHODS: we studied 592 HF patients who had been hospitalized for HF and were followed for 18 months. The primary end-point was a composite of all-cause mortality and HF hospitalization. RESULTS: a doubling of galectin-3 levels was associated with a hazard ratio (HR) of 1.97 (1.62-2.42) for the primary outcome (P < 0.001). After correction for age, gender, BNP, eGFR, and diabetes the HR was 1.38 (1.07-1.78; P = 0.015). Galectin-3 levels were correlated with higher IL-6 and CRP levels (P < 0.002). Changes of galectin-3 levels after 6 months did not add prognostic information to the base-line value (n = 291); however, combining plasma galectin-3 and BNP levels increased prognostic value over either biomarker alone (ROC analysis, P < 0.05). The predictive value of galectin-3 was stronger in patients with preserved LVEF (n = 114) compared to patients with reduced LVEF (P < 0.001). CONCLUSIONS: galectin-3 is an independent marker for outcome in HF and appears to be particularly useful in HF patients with preserved LVEF.
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