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Glutathione in the ...
Glutathione in the blood and cerebrospinal fluid: A study in healthy male volunteers
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- Samuelsson, Martin (author)
- Östergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken
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- Vainikka, Linda (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Öllinger, Karin (author)
- Östergötlands Läns Landsting,Linköpings universitet,Experimentell patologi,Hälsouniversitetet,Klinisk patologi och klinisk genetik
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(creator_code:org_t)
- Elsevier, 2011
- 2011
- English.
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In: Neuropeptides. - : Elsevier. - 0143-4179 .- 1532-2785. ; 45:4, s. 287-292
- Related links:
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Glutathione (GSH) is an important regulator of intracellular redox homeostasis. In the brain, glutathione is considered a major antioxidant, which is also found at high concentrations in the extracellular environment. Altered GSH balance in plasma, blood and cerebrospinal fluid (CSF) has been observed in several disorders suggesting that an impaired antioxidant function is part of the pathophysiology. The aim of the present study was to investigate a possible relationship between glutathione in plasma and CSF. Blood samples were collected from 26 healthy male volunteers at 8 a.m., noon, 4 p.m. and 8 p.m. At 8 a.m. the following morning, blood was drawn and three 6-ml fractions of CSF were collected by lumbar puncture. In CSF, a disrupted gradient was found showing the highest glutathione concentration in the second compared to the first and third fraction (P andlt; 0.002). Moreover, correlation and regression analyses between glutathione in plasma and CSF revealed an association between the third fraction CSF and plasma glutathione 8 p.m. the day before lumbar puncture. Thus, if carefully standardised due to the disrupted gradient in CSF, it might be possible to estimate glutathione levels in CSF by analysing plasma in healthy males.
Keyword
- Glutathione
- Plasma
- Blood
- Cerebrospinal fluid
- Lumbar puncture
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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