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A Population-based ...
A Population-based Investigation of the Autoantibody Profile in Mothers of Children with Atrioventricular Block
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- Salomonsson, S. (author)
- Karolinska Institutet,Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden,Department of Rheumatology, Umeå University, Sweden,Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden
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- Dzikaite, V. (author)
- Karolinska Institutet,Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
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- Zeffer, E. (author)
- Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
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- Eliasson, H. (author)
- Karolinska Institutet,Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden
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- Ambrosi, A. (author)
- Karolinska Institutet,Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden,Department of Clinical Sciences, Paediatrics, Umeå University, Sweden,Uppsala University
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- Bergman, G. (author)
- Karolinska Institutet,Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden
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- Fernlund, E. (author)
- Skåne University Hospital, Malmö,Department of Pediatric Cardiology, Skane University Hospital, Lund, Sweden
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- Theander, Elke (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Rheumatology Department, Skåne University Hospital, Malmö, Sweden
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- Öhman, Annika, 1971- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Perinatal, neonatal och barnkardiologisk forskning/Jonzon
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- Rydberg, Annika (author)
- Umeå universitet,Pediatrik
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- Skogh, Thomas (author)
- Östergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Reumatologiska kliniken i Östergötland,Rheumatology/AIR, Clinical and Experimental Medicine, Linköping University, Sweden
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- Wållberg-Jonsson, Solveig (author)
- Umeå universitet,Reumatologi
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- Elfving, Å. (author)
- Karolinska Institutet, Stockholm
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- Fored, M. (author)
- Karolinska Institutet,Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
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- Ekbom, A. (author)
- Karolinska Institutet, Stockholm
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- Lundström, U. (author)
- Department of Pediatric Cardiology, The Queen Silvia Children′s Hospital, Sahlgrenska University Hospital, Göteborg, Sweden
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- Mellander, M. (author)
- Karolinska Institutet,Department of Pediatric Cardiology, The Queen Silvia Children′s Hospital, Sahlgrenska University Hospital, Göteborg, Sweden,Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
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- Winqvist, O. (author)
- Karolinska Institutet,Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
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- Sonesson, S.-E. (author)
- Karolinska Institutet, Stockholm
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- Gadler, F. (author)
- Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
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- Jonzon, Anders, 1948- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Perinatal, neonatal och barnkardiologisk forskning/Jonzon
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- Wahren-Herlenius, M. (author)
- Karolinska Institutet, Stockholm
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(creator_code:org_t)
- 2011-10-05
- 2011
- English.
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In: Scandinavian Journal of Immunology. - Oxford : Blackwell Publishing. - 0300-9475 .- 1365-3083. ; 74:5, s. 511-517
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Abstract
Subject headings
Close
- The objective of the study was to investigate the antigen specificity and occurrence of individual autoantibodies in mothers of children diagnosed with atrioventricular (AV) block in a nation-wide setting. Patients with AV block detected before 15 years of age were identified using national quality registries as well as a network of pediatric and adult cardiologists and rheumatologists at the six university hospitals in Sweden. Patients with gross heart malformations, surgically or infectiously induced blocks were excluded. Blood samples were obtained from the mothers and maternal autoantibody profile, including the occurrence of antibodies against Ro52, Ro60, La, SmB, SmD, RNP-70k, RNP-A, RNP-C, CENP-C, Scl-70, Jo-1, ribosomal RNP and histones was investigated in 193 mothers of children with AV block by immunoblotting and ELISA. Autoantibody reactivity was detected in 48% (93/193) of the mothers of children with AV block. In autoantibody-positive mothers, the vast majority, 95% (88/93), had antibodies against Ro52, while 63% (59/93) had autoantibodies to Ro60 and 58% (54/93) had autoantibodies to La. In addition, 13% (12/93) of the autoantibody-positive mothers had antibodies to other investigated antigens besides Ro52, Ro60 and La, and of these anti-histone antibodies were most commonly represented, detected in 8% (7/93) of the mothers. In conclusion, this Swedish population-based study confirms that maternal autoantibodies may associate with heart block in the child. Further, our data demonstrate a dominant role of Ro52 antibodies in association with AV block.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Salomonsson, S.
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Dzikaite, V.
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Zeffer, E.
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Eliasson, H.
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Ambrosi, A.
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Bergman, G.
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show more...
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Fernlund, E.
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Theander, Elke
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Öhman, Annika, 1 ...
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Rydberg, Annika
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Skogh, Thomas
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Wållberg-Jonsson ...
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Elfving, Å.
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Fored, M.
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Ekbom, A.
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Lundström, U.
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Mellander, M.
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Winqvist, O.
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Sonesson, S.-E.
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Gadler, F.
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Jonzon, Anders, ...
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Wahren-Herlenius ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Scandinavian Jou ...
- By the university
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Linköping University
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Umeå University
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Lund University
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Karolinska Institutet
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Uppsala University