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  • Salomonsson, S.Karolinska Institutet,Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden,Department of Rheumatology, Umeå University, Sweden,Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden (author)

A Population-based Investigation of the Autoantibody Profile in Mothers of Children with Atrioventricular Block

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-10-05
  • Oxford :Blackwell Publishing,2011
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-72019
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-72019URI
  • https://doi.org/10.1111/j.1365-3083.2011.02610.xDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45884URI
  • https://lup.lub.lu.se/record/2151465URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123467520URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-161434URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|KIRCNET (Karolinska Institutet Circulation and Respiratory Research Network)||Magn Bergvalls Foundation||Jerringfoundation||Stiftelsen Samariten||Karolinska Institute||Royal Swedish Academy of Sciences||Swedish Research Council||Goran Gustafsson Foundation||Torsten and Ragnar Soderberg Foundation||King Gustaf the V:th 80-year foundation||Swedish Foundation for Strategic Research||Heart-Lung Foundation||Swedish Rheumatism Association||
  • The objective of the study was to investigate the antigen specificity and occurrence of individual autoantibodies in mothers of children diagnosed with atrioventricular (AV) block in a nation-wide setting. Patients with AV block detected before 15 years of age were identified using national quality registries as well as a network of pediatric and adult cardiologists and rheumatologists at the six university hospitals in Sweden. Patients with gross heart malformations, surgically or infectiously induced blocks were excluded. Blood samples were obtained from the mothers and maternal autoantibody profile, including the occurrence of antibodies against Ro52, Ro60, La, SmB, SmD, RNP-70k, RNP-A, RNP-C, CENP-C, Scl-70, Jo-1, ribosomal RNP and histones was investigated in 193 mothers of children with AV block by immunoblotting and ELISA. Autoantibody reactivity was detected in 48% (93/193) of the mothers of children with AV block. In autoantibody-positive mothers, the vast majority, 95% (88/93), had antibodies against Ro52, while 63% (59/93) had autoantibodies to Ro60 and 58% (54/93) had autoantibodies to La. In addition, 13% (12/93) of the autoantibody-positive mothers had antibodies to other investigated antigens besides Ro52, Ro60 and La, and of these anti-histone antibodies were most commonly represented, detected in 8% (7/93) of the mothers. In conclusion, this Swedish population-based study confirms that maternal autoantibodies may associate with heart block in the child. Further, our data demonstrate a dominant role of Ro52 antibodies in association with AV block.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Dzikaite, V.Karolinska Institutet,Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (author)
  • Zeffer, E.Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (author)
  • Eliasson, H.Karolinska Institutet,Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden (author)
  • Ambrosi, A.Karolinska Institutet,Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden,Department of Clinical Sciences, Paediatrics, Umeå University, Sweden,Uppsala University (author)
  • Bergman, G.Karolinska Institutet,Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden (author)
  • Fernlund, E.Skåne University Hospital, Malmö,Department of Pediatric Cardiology, Skane University Hospital, Lund, Sweden (author)
  • Theander, ElkeLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Rheumatology Department, Skåne University Hospital, Malmö, Sweden(Swepub:lu)medf-eth (author)
  • Öhman, Annika,1971-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Perinatal, neonatal och barnkardiologisk forskning/Jonzon(Swepub:uu)annoh601 (author)
  • Rydberg, AnnikaUmeå universitet,Pediatrik(Swepub:umu)anry0014 (author)
  • Skogh, ThomasÖstergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Reumatologiska kliniken i Östergötland,Rheumatology/AIR, Clinical and Experimental Medicine, Linköping University, Sweden(Swepub:liu)thosk00 (author)
  • Wållberg-Jonsson, SolveigUmeå universitet,Reumatologi(Swepub:umu)sowa0001 (author)
  • Elfving, Å.Karolinska Institutet, Stockholm (author)
  • Fored, M.Karolinska Institutet,Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (author)
  • Ekbom, A.Karolinska Institutet, Stockholm (author)
  • Lundström, U.Department of Pediatric Cardiology, The Queen Silvia Children′s Hospital, Sahlgrenska University Hospital, Göteborg, Sweden (author)
  • Mellander, M.Karolinska Institutet,Department of Pediatric Cardiology, The Queen Silvia Children′s Hospital, Sahlgrenska University Hospital, Göteborg, Sweden,Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (author)
  • Winqvist, O.Karolinska Institutet,Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (author)
  • Sonesson, S.-E.Karolinska Institutet, Stockholm (author)
  • Gadler, F.Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (author)
  • Jonzon, Anders,1948-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Perinatal, neonatal och barnkardiologisk forskning/Jonzon(Swepub:uu)andersjz (author)
  • Wahren-Herlenius, M.Karolinska Institutet, Stockholm (author)
  • Karolinska InstitutetDepartment of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (creator_code:org_t)

Related titles

  • In:Scandinavian Journal of ImmunologyOxford : Blackwell Publishing74:5, s. 511-5170300-94751365-3083

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