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  • Merabet, SamirUniversité de la Méditerranée, Marseille, France (author)

Insights into Hox Protein Function from a Large Scale Combinatorial Analysis of Protein Domains

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-10-27
  • PLoS,2011
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-72180
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-72180URI
  • https://doi.org/10.1371/journal.pgen.1002302DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies|CNRS||Universite de la Mediterranee||ANR||FRM||CEFIPRA||ARC||Swedish Research Council||Swedish Strategic Research Foundation||Knut and Alice Wallenberg Foundation||Swedish "Hjarnfonden," "Cancerfonden,"||Swedish Royal Academy of Sciences||Universite de la Mediterrannee||AFM||
  • Protein function is encoded within protein sequence and protein domains. However, how protein domains cooperate within a protein to modulate overall activity and how this impacts functional diversification at the molecular and organism levels remains largely unaddressed. Focusing on three domains of the central class Drosophila Hox transcription factor AbdominalA (AbdA), we used combinatorial domain mutations and most known AbdA developmental functions as biological readouts to investigate how protein domains collectively shape protein activity. The results uncover redundancy, interactivity, and multifunctionality of protein domains as salient features underlying overall AbdA protein activity, providing means to apprehend functional diversity and accounting for the robustness of Hox-controlled developmental programs. Importantly, the results highlight context-dependency in protein domain usage and interaction, allowing major modifications in domains to be tolerated without general functional loss. The non-pleoitropic effect of domain mutation suggests that protein modification may contribute more broadly to molecular changes underlying morphological diversification during evolution, so far thought to rely largely on modification in gene cis-regulatory sequences.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Litim-Mecheri, IsmaUniversité de la Méditerranée, Marseille, France (author)
  • Karlsson, DanielLinköpings universitet,Utvecklingsbiologi,Hälsouniversitetet(Swepub:liu)danka67 (author)
  • Dixit, RichaTata Institute of Fundamental Research, Bangalore, India (author)
  • Saadaoui, MehdiUniversité de la Méditerranée, Marseille, France (author)
  • Monier, BrunoUniversité de la Méditerranée, Marseille, France (author)
  • Brun, ChristineUniversité de la Méditerranée, Marseille, France (author)
  • Thor, StefanLinköpings universitet,Utvecklingsbiologi,Hälsouniversitetet(Swepub:liu)steth80 (author)
  • Vijayraghavan, KTata Institute of Fundamental Research, Bangalore, India (author)
  • Perrin, LaurentUniversité de la Méditerranée, Marseille, France (author)
  • Pradel, JacquesUniversité de la Méditerranée, Marseille, France (author)
  • Graba, YacineUniversité de la Méditerranée, Marseille, France (author)
  • Université de la Méditerranée, Marseille, FranceUtvecklingsbiologi (creator_code:org_t)

Related titles

  • In:PLoS Genetics: PLoS7:101553-73901553-7404

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