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NK Cell Function an...
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Johansson, Susanne EKarolinska Institute
(author)
NK Cell Function and Antibodies Mediating ADCC in HIV-1-Infected Viremic and Controller Patients
- Article/chapterEnglish2011
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Mary Ann Liebert,2011
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:liu-72265
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-72265URI
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https://doi.org/10.1089/vim.2011.0025DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:123507220URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies|Swedish Research Council||Swedish International Development Cooperation Agency (SIDA)||Swedish Physicians Against AIDS Research Foundation||
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Natural killer (NK) cells have been suggested to play a protective role in HIV disease progression. One potent effector mechanism of NK cells is antibody-dependent cellular cytotoxicity (ADCC) mediated by antiviral antibodies binding to the Fc gamma RIIIa receptor (CD16) on NK cells. We investigated NK cell-mediated ADCC function and the presence of ADCC antibodies in plasma from 20 HIV-1-infected patients and 10 healthy donors. The HIV-positive patients were divided into two groups: six who controlled viremia for at least 8 y without treatment (controllers), and 14 who were persistently viremic and not currently on treatment. Plasma from both patient groups induced NK cell IFN-gamma expression and degranulation in response to HIV-1 envelope (Env) gp140-protein-coated cells. Patient antibodies mediating ADCC were largely directed towards the Env V3 loop, as identified by a gp140 protein lacking the V3 loop. Interestingly, in two controllers ADCC-mediating antibodies were more broadly directed to other parts of Env. A high viral load in patients correlated with decreased ADCC-mediated cytolysis of gp140-protein-coated target cells. NK cells from both infected patients and healthy donors degranulated efficiently in the presence of antibody-coated HIV-1-infected Jurkat cells. In conclusion, the character of ADCC-mediating antibodies differed in some controllers compared to viremic patients. NK cell ADCC activity is not compromised in HIV-infected patients.
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Rollman, ErikUniversity of Melbourne
(author)
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Chung, Amy WUniversity of Melbourne
(author)
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Center, Rob JUniversity of Melbourne
(author)
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Hejdeman, BoKarolinska Institutet
(author)
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Stratov, IvanUniversity of Melbourne
(author)
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Hinkula, JormaLinköpings universitet,Molekylär virologi,Hälsouniversitetet(Swepub:liu)jorhi40
(author)
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Wahren, BrittaKarolinska Institutet
(author)
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Kaerre, KlasKarolinska Institutet
(author)
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Kent, Stephen JUniversity of Melbourne
(author)
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Berg, LouiseKarolinska Institutet
(author)
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Karolinska InstituteUniversity of Melbourne
(creator_code:org_t)
Related titles
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In:Viral immunology: Mary Ann Liebert24:5, s. 359-3680882-82451557-8976
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Johansson, Susan ...
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Rollman, Erik
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Chung, Amy W
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Center, Rob J
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Hejdeman, Bo
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Stratov, Ivan
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show more...
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Hinkula, Jorma
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Wahren, Britta
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Kaerre, Klas
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Kent, Stephen J
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Berg, Louise
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Viral immunology
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Linköping University
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Karolinska Institutet