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  • Johansson, Susanne EKarolinska Institute (author)

NK Cell Function and Antibodies Mediating ADCC in HIV-1-Infected Viremic and Controller Patients

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Mary Ann Liebert,2011
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-72265
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-72265URI
  • https://doi.org/10.1089/vim.2011.0025DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123507220URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Research Council||Swedish International Development Cooperation Agency (SIDA)||Swedish Physicians Against AIDS Research Foundation||
  • Natural killer (NK) cells have been suggested to play a protective role in HIV disease progression. One potent effector mechanism of NK cells is antibody-dependent cellular cytotoxicity (ADCC) mediated by antiviral antibodies binding to the Fc gamma RIIIa receptor (CD16) on NK cells. We investigated NK cell-mediated ADCC function and the presence of ADCC antibodies in plasma from 20 HIV-1-infected patients and 10 healthy donors. The HIV-positive patients were divided into two groups: six who controlled viremia for at least 8 y without treatment (controllers), and 14 who were persistently viremic and not currently on treatment. Plasma from both patient groups induced NK cell IFN-gamma expression and degranulation in response to HIV-1 envelope (Env) gp140-protein-coated cells. Patient antibodies mediating ADCC were largely directed towards the Env V3 loop, as identified by a gp140 protein lacking the V3 loop. Interestingly, in two controllers ADCC-mediating antibodies were more broadly directed to other parts of Env. A high viral load in patients correlated with decreased ADCC-mediated cytolysis of gp140-protein-coated target cells. NK cells from both infected patients and healthy donors degranulated efficiently in the presence of antibody-coated HIV-1-infected Jurkat cells. In conclusion, the character of ADCC-mediating antibodies differed in some controllers compared to viremic patients. NK cell ADCC activity is not compromised in HIV-infected patients.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rollman, ErikUniversity of Melbourne (author)
  • Chung, Amy WUniversity of Melbourne (author)
  • Center, Rob JUniversity of Melbourne (author)
  • Hejdeman, BoKarolinska Institutet (author)
  • Stratov, IvanUniversity of Melbourne (author)
  • Hinkula, JormaLinköpings universitet,Molekylär virologi,Hälsouniversitetet(Swepub:liu)jorhi40 (author)
  • Wahren, BrittaKarolinska Institutet (author)
  • Kaerre, KlasKarolinska Institutet (author)
  • Kent, Stephen JUniversity of Melbourne (author)
  • Berg, LouiseKarolinska Institutet (author)
  • Karolinska InstituteUniversity of Melbourne (creator_code:org_t)

Related titles

  • In:Viral immunology: Mary Ann Liebert24:5, s. 359-3680882-82451557-8976

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