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Development of a ha...
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Andersson, KjellSwedish National Laboratory of Forensic Science
(författare)
Development of a harmonised method for the profiling of amphetamines : III. Development of the gas chromatographic method
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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Elsevier,2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-72288
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-72288URI
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https://doi.org/10.1016/j.forsciint.2006.10.018DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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This study focused on gas chromatographic analysis of target compounds found in illicit amphetamine synthesised by the Leuckart reaction, reductive amination of benzyl methyl ketone, and the nitrostyrene route. The analytical method was investigated and optimised with respect to introduction of amphetamine samples into the gas chromatograph and separation and detection of the target substances. Sample introduction using split and splitless injection was tested at different injector temperatures, and their ability to transfer the target compounds to the GC column was evaluated using cold on column injection as a reference. Taking the results from both techniques into consideration a temperature of 250 °C was considered to be the best compromise. The most efficient separation was achieved with a DB-35MS capillary column (35% diphenyl 65% dimethyl silicone; 30 m × 0.25 mm, df 0.25 μm) and an oven temperature program that started at 90 °C (1 min) and was increased by 8 °C/min to 300 °C (10 min). Reproducibility, repeatability, linearity, and limits of determination for the flame ionisation detector (FID), nitrogen phosphorous detector (NPD), and mass spectrometry (MS) in scan mode and selected ion monitoring (SIM) mode were evaluated. In addition, selectivity was studied applying FID and MS in both scan and SIM mode. It was found that reproducibility, repeatability, and limits of determination were similar for FID, NPD, and MS in scan mode. Moreover, the linearity was better when applying FID or NPD whereas the selectivity was better when utilising the MS. Finally, the introduction of target compounds to the GC column when applying injection volumes of 0.2 μl, 1 μl, 2 μl, and 4 μl with splitless injection respectively 1 μl with split injection (split ratio, 1:40) were compared. It was demonstrated that splitless injections of 1 μl, 2 μl, and 4 μl could be employed in the developed method, while split injection and splitless injections of 0.2 μl should be avoided.
Ämnesord och genrebeteckningar
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Amphetamine; Impurities; Profiling; Optimisation; Separation; Gas chromatography–mass spectrometry
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TECHNOLOGY
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TEKNIKVETENSKAP
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jalava, KaisaNational Bureau of Investigation, Finland
(författare)
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Lock, EricUniversity of Lausanne
(författare)
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Finnon, YvonneUniversity of Strathclyde, Glasgow
(författare)
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Huizer, HenkNetherlands Forensic Institute
(författare)
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Kaa, ElisabetUniversity of Aarhus
(författare)
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Lopes, AlvaroPolicia Judiciaria, Lisbon, Portugal
(författare)
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Poortman-Van der Meer, AnnekeNetherlands Forensic Institute
(författare)
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Cole, Michael D.University of Strathclyde, Glasgow
(författare)
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Dahlén, JohanSwedish National Laboratory of Forensic Science(Swepub:liu)johda32
(författare)
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Sippola, ErkkiNational Bureau of Investigation, Finland
(författare)
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Swedish National Laboratory of Forensic ScienceNational Bureau of Investigation, Finland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Forensic Science International: Elsevier169:1, s. 50-630379-07381872-6283
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Andersson, Kjell
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Jalava, Kaisa
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Lock, Eric
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Finnon, Yvonne
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Huizer, Henk
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Kaa, Elisabet
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visa fler...
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Lopes, Alvaro
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Poortman-Van der ...
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Cole, Michael D.
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Dahlén, Johan
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Sippola, Erkki
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