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  • Lock, EricUniversity of Lausanne (author)

Development of a harmonised method for the profiling of amphetamines V : Determination of the variability of the optimised method

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • Elsevier,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-72290
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-72290URI
  • https://doi.org/10.1016/j.forsciint.2006.10.019DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • This paper is the fifth in a series of six in relation to the development of a harmonised method for the profiling of amphetamine [L. Aalberg, K. Andersson, C. Bertler, H. Borén, M.D. Cole, J. Dahlén, Y. Finnon, H. Huizer, K. Jalava, E. Kaa, E. Lock, A. Lopes, A. Poortman-van der Meer, E. Sippola, Development of a harmonised method for the profiling of amphetamines I. Synthesis of standards and compilation of analytical data, Forensic Sci. Int. 149 (2005) 219–229; L. Aalberg, K. Andersson, C. Bertler, M.D. Cole, Y. Finnon, H. Huizer, K. Jalava, E. Kaa, E. Lock, A. Lopes, A. Poortman-van der Meer, E. Sippola, J. Dahlén, Development of a harmonised method for the profiling of amphetamines II. Stability of impurities in organic solvents, Forensic Sci. Int. 149 (2005) 231–241]. The third paper [K. Andersson, K. Jalava, E. Lock, L. Aalberg, Y. Finnon, H. Huizer, E. Kaa, A. Lopes, A. Poortman-van der Meer, M.D. Cole, J. Dahlén, E. Sippola, Development of a harmonised method for the profiling of amphetamines III. Development of the gas chromatographic method, Forensic Sci. Int., in press] dealt with the optimisation of the gas chromatographic and detection methods whereas the fourth paper [K. Andersson, K. Jalava, E. Lock, Y. Finnon, S. Stevenson, L. Aalberg, H. Huizer, E. Kaa, A. Lopes, A. Poortman-van der Meer, M.D. Cole, J. Dahlén, E. Sippola, Development of a harmonised method for the profiling of amphetamines IV. Optimisation of sample preparation, Forensic Sci. Int., in press] concerned the optimisation of the extraction method prior to GC analysis.This paper is a study of the optimised method in order to determine its stability. Investigations of within and between day variations were carried out in four laboratories. Moreover, variations between laboratories were also determined. Both flame ionisation detector (FID) and MS detection were used. One laboratory studied nitrogen-phosphorous detector (NPD) detection as well. For this task, 12 batches of amphetamine were prepared. Six of them were synthesised via the Leuckart route, three via the nitrostyrene route and three via the reductive amination route [A.M.A. Verweij, Impurities in illicit drug preparations: amphetamine and methamphetamine, Forensic Sci. Rev. 1 (1989) 2–11].Taking into account all studied target compounds and the average results from four laboratories, the within day variation was around 6% for FID and 5% for MS, the between days variation was around 10% for FID and 8% for MS. For NPD detection, within day variation was 5% and between days variation 9% (only one laboratory). Finally, the inter-laboratory variation was about 12% for FID (four laboratories) and 10% for MS (three laboratories).

Subject headings and genre

  • Amphetamine; Profiling; GC-FID; GC–MS; GC-NPD; Inter-laboratory variation
  • TECHNOLOGY
  • TEKNIKVETENSKAP

Added entries (persons, corporate bodies, meetings, titles ...)

  • Aalberg, LauraNational Bureau of Investigation, Finland (author)
  • Andersson, KjellSwedish National Laboratory of Forensic Science (author)
  • Dahlén, JohanSwedish National Laboratory of Forensic Science(Swepub:liu)johda32 (author)
  • Cole, Michael D.University of Strathclyde, Glasgow (author)
  • Finnon, YvonneUniversity of Strathclyde, Glasgow (author)
  • Huizer, HenkNetherlands Forensic Institute (author)
  • Jalava, KaisaNational Bureau of Investigation, Finland (author)
  • Kaa, ElisabetUniversity of Aarhus (author)
  • Lopes, AlvaroPolicia Judiciaria, Lisbon, Portugal (author)
  • Poortman-Van der Meer, AnnekeNetherlands Forensic Institute (author)
  • Sippola, ErwNational Bureau of Investigation, Finland (author)
  • University of LausanneNational Bureau of Investigation, Finland (creator_code:org_t)

Related titles

  • In:Forensic Science International: Elsevier169:1, s. 77-850379-07381872-6283

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