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Sökning: WFRF:(Zeng Zhi) > (2010-2014) > Nup88 mRNA overexpr...

  • Zhao, Zeng-RenHebei Medical University (författare)

Nup88 mRNA overexpression in colorectal cancers and relationship with p53

  • Artikel/kapitelEngelska2010

Förlag, utgivningsår, omfång ...

  • IOS Press,2010
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-72966
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-72966URI
  • https://doi.org/10.3233/DMA-2011-0842DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objectives: We measured nucleoporin 88 (Nup88) mRNA expression in primary colorectal cancers to investigate its relationship with clinicopathological features and p53. Methods: The primary cancer tissues, adjacent noncancerous tissues and the proximal and distant margins of normal mucosa were collected from 73 colorectal cancer patients during surgery. Nup88 mRNA expression was measured on these fresh specimens and on colon cell lines HCT-116 (P53+/+) and HCT-116 (P53-/-) by RT-PCR while p53 mRNA and beta-actin as controls. Nup88 and p53 protein expression were then immunohistochemistrically examined in other 25 colorectal cancers specimens paraffin embedded and formalin fixed. Results: Nup88 expression was higher in primary cancer tissues than in adjacent noncancerous tissues, and in the proximal and distant margins of normal mucosa. Overexpression of Nup88 mRNA was statistically associated with TNM stage (P = 0.044), lymphatic metastasis (P = 0.022), and cancer location (P = 0.036), while not related to gender, age of patients and histological type, infiltration depth, and differentiation of cancers. The expression of Nup88 mRNA in the HCT-116 (P53-/-) cell line was not significantly different from expression in the HCT-116 (P53+/+) cell line. And there was no correlation between Nup88 and p53 protein expression (r = 0.632, P = 0.368). Conclusions: Nup88 mRNA was overexpressed in colorectal cancers and the overexpression was associated with cancer development and aggressiveness. Nup88 might be regard as essential contributor to nodal metastagenicity of colorectal cancer.

Ämnesord och genrebeteckningar

  • Nup88; p53; mRNA; RT-PCR
  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zhang, Zhi-YongTangshan Gongren Hospital (författare)
  • He, Xin-QiHebei Medical University (författare)
  • Hu, Yue-MingTangshan Gongren Hospital (författare)
  • Tian, Yan-FengHebei Medical University (författare)
  • Zhang, Li-JingHebei Medical University (författare)
  • Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)xiasu45 (författare)
  • Hebei Medical UniversityTangshan Gongren Hospital (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:CANCER BIOMARKERS: IOS Press8:2, s. 73-801574-0153

Internetlänk

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