Downregulation of caspase-10 predicting poor survival after resection of stage II colorectal cancer

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Shen, Xiao-GangSichuan University (författare)

Downregulation of caspase-10 predicting poor survival after resection of stage II colorectal cancer

Artikel/kapitelEngelska2011

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2011-05-11
Springer Verlag (Germany),2011
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LIBRIS-ID:oai:DiVA.org:liu-73099
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73099URI
https://doi.org/10.1007/s00384-011-1239-zDOI

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Språk:engelska
Sammanfattning på:engelska

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Funding Agencies|National Natural Science Founding of China|30801331|
Purpose The aim of this study was to evaluate the prevalence and clinical significance of caspase-10 mRNA expression in stage II colorectal cancer. less thanbrgreater than less thanbrgreater thanMethods Quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) was used to analyze caspase-10 expression in cancer tissue and corresponding normal mucosa from 120 patients with stage II colorectal cancer. Variables were analyzed by Chi-square test or Fishers exact test. Survival was evaluated with method of Kaplan-Meier. Multivariate analysis was performed with Coxs proportional hazards model. less thanbrgreater than less thanbrgreater thanResults The expression of caspase-10 mRNA was found to be downregulated in cancer tissue compared to normal mucosa (P = 0.001). Poorly differentiated cancer showed lower mRNA expression than cancer with greater differentiation (P = 0.031). Univariate survival curves, estimated using the method of Kaplan-Meier, defined a significant association between caspase-10 expression and both overall survival (P = 0.012) and disease-free survival (P = 0.021). A multivariate analysis, performed by Coxs proportional hazards regression model, confirmed that a low caspase-10 expression was the only significant factor to predict poor prognosis in patients with stage II colorectal cancer. less thanbrgreater than less thanbrgreater thanConclusion Our data indicate that caspase-10 expression, measured by quantitative real-time RT-PCR, is a possible prognostic factor in patients with stage II colorectal cancer.

Ämnesord och genrebeteckningar

Apoptosis
Caspase-10
Colorectal cancer
Stage II
Survival
MEDICINE
MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

Wang, CunSichuan University (författare)
Li, YuanSichuan University (författare)
Zhou, BinSichuan University (författare)
Xu, BinSichuan University (författare)
Yang, LieSichuan University (författare)
Zhou, Zong-GuangSichuan University (författare)
Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)xiasu45 (författare)
Sichuan UniversityOnkologi (creator_code:org_t)

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Ingår i:International Journal of Colorectal Disease: Springer Verlag (Germany)26:12, s. 1519-15240179-19581432-1262

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International Journal of Colorectal Disease (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Shen, Xiao-Gang; Wang, Cun; Li, Yuan; Zhou, Bin; Xu, Bin; Yang, Lie; visa fler...; Zhou, Zong-Guang; Sun, Xiao-Feng; visa färre...

Artiklar i publikationen: International Jo ...

Av lärosätet: Linköpings universitet

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