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  • Welinder, EvaLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine,Lund Stem Cell Center, BMC B10, Lund (author)

B-lymphocyte commitment : Identifying the point of no return

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Elsevier,2011
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:liu-73346
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73346URI
  • https://doi.org/10.1016/j.smim.2011.08.005DOI
  • https://lup.lub.lu.se/record/2168431URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Even though B-lymphocyte development is one of the best understood models for cell differentiation in the hematopoetic system, recent advances in cell sorting and functional genomics has increased this understanding further. This has suggested that already early lymphoid primed multipotent progenitor cells (LMPPs) express low levels of lymphoid restricted transcripts. The expression of these genes becomes more pronounced when cells enter the FLT-3/IL-7 receptor positive common lymphoid progenitor (CLP) stage. However, the expression of B-lineage specific genes is limited to a B-cell restricted Ly6D surface positive subpopulation of the CLP compartment. The gene expression patterns also reflect differences in lineage potential and while Ly6D negative FLT-3/IL-7 receptor positive cells represents true CLPs with an ability to generate B/T and NK cells, the Ly6D positive cells lack NK cell potential and display a reduced T-cell potential in vivo. These recent findings suggest that the CLP compartment is highly heterogenous and that the point of no return in B-cell development may occur already in B220(-) CD19(-) cells. These findings have allowed for a better understanding of the interplay between transcription factors like EBF-1, PAX-5 and E47, all known as crucial for normal B-cell development. In this review, we aim to provide a comprehensive overview of B-cell fate specification and commitment based on the recent advances in the understanding of molecular networks as well as functional properties of early progenitor populations. (C) 2011 Elsevier Ltd. All rights reserved.

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  • Åhsberg, JosefineLinköpings universitet,Experimentell hematologi,Hälsouniversitetet(Swepub:liu)josbe59 (author)
  • Sigvardsson, MikaelLund University,Lunds universitet,Linköpings universitet,Experimentell hematologi,Hälsouniversitetet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-msi (author)
  • Institutionen för experimentell medicinsk vetenskapMedicinska fakulteten (creator_code:org_t)

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  • In:Seminars in Immunology: Elsevier23:5, s. 335-3401044-53231096-3618

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