SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Angleitner A)
 

Search: WFRF:(Angleitner A) > Prognostic nomogram...

  • Lee, C.K.University of Sydney (author)

Prognostic nomogram to predict progression-free survival in patients with platinum-sensitive recurrent ovarian cancer

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-09-13
  • Cancer Research UK,2011
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-73593
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73593URI
  • https://doi.org/10.1038/bjc.2011.364DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Patients with platinum-sensitive recurrent ovarian cancer are a heterogeneous group, and it is not possible to accurately predict the progression-free survival (PFS) in these patients. We developed and validated a nomogram to help improve prediction of PFS in patients treated with platinum-based chemotherapy. METHODS: The nomogram was developed in a training cohort (n = 955) from the CALYPSO trial and validated in the AGO-OVAR 2.5 Study (n = 340). The proportional-hazards model (nomogram) was based on pre-treatment characteristics. RESULTS: The nomogram had a concordance index (C-index) of 0.645. Significant predictors were tumour size platinum-chemotherapy-free interval, CA-125, number of organ metastatic sites and white blood count. When the nomogram was applied without CA-125 (CA-125 was not available in validation cohort), the C-indices were 0.624 (training) and 0.594 (validation). When classification was based only on the platinum-chemotherapy-free interval, the indices were 0.571 (training) and 0.560 (validation). The calibration plot in the validation cohort based on four predictors (without CA-125) suggested good agreement between actual and nomogram-predicted 12-month PFS probabilities. CONCLUSION: This nomogram, using five pre-treatment characteristics, improves prediction of PFS in patients with platinum-sensitive ovarian cancer having platinum-based chemotherapy. It will be useful for the design and stratification of patients in clinical trials and also for counselling patients. 

Subject headings and genre

  • nomogram; recurrent ovarian cancer; prognosis; platinum sensitivity; progression-free survival
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Simes, R.J.University of Sydney (author)
  • Brown, C.University of Sydney (author)
  • Lord, S.University of Sydney (author)
  • Wagner, U.University Hospital Giessen and Marburg (author)
  • Plante, M.CHUQ Hotel Dieu Quebec (author)
  • Vergote, I.University Hospital Leuven (author)
  • Pisano, C.National Cancer Institute, Naples (author)
  • Parma, G.European Institute for Oncology (author)
  • Burges, A.Klinikum University of Munic (author)
  • Bourgeois, H.Centre Jean Bernard SARL SORECOH (author)
  • Hogberg, T.Östergötlands Läns Landsting,Onkologiska kliniken US (author)
  • Bentley, J.Dalhousie University, Halifax, NS B3H 1V7, Canada (author)
  • Angleitner-Boubenizek, L.BHS Linz, A-4020 Linz, Austria (author)
  • Ferrero, A.Mauriziano Hospital, Academic Div Gynecol Oncol, Turin, Italy (author)
  • Richter, B.University of Dresden, Department Gynecol and Obstet, Dresden, Germany (author)
  • Hirte, H.Juravinski Cancer Centre Hamilton Health Science, Hamilton, ON, Canada (author)
  • Gebski, V.University of Sydney, NHMRC Clin Trials Centre, Camperdown, NSW 1450, Australia (author)
  • Pfisterer, J.Staedt Klinikum Solingen, Department Gynecol, D-42653 Solingen, Germany (author)
  • Pujade-Lauraine, E.University of Paris 05, Hop University of Paris Centre, AP HP, F-75004 Paris, France (author)
  • Friedlander, M.Prince Wales Hospital, Institute Oncol, Sydney, NSW 2031, Australia (author)
  • University of SydneyUniversity Hospital Giessen and Marburg (creator_code:org_t)

Related titles

  • In:British Journal of Cancer: Cancer Research UK105:8, s. 1144-11500007-09201532-1827

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view