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Quantifying differe...
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Dahlqvist Leinhard, Olof,1978-Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiofysik,Hälsouniversitetet
(författare)
Quantifying differences in hepatic uptake of the liver specific contrast agents Gd-EOB-DTPA and Gd-BOPTA : a pilot study
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2011-10-09
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Springer Berlin/Heidelberg,2012
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-73624
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73624URI
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https://doi.org/10.1007/s00330-011-2302-4DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:123983414URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The previous status of this article was Manuscript and the working titles was Liver Specific Gd-EOB-DTPA vs. Gd-BOPTA Uptake in Healthy Subjects: A Novel and Quantitative MRI Analysis of Hepatic Uptake and Vascular Enhancement and Hepatic Uptake of Gd-EOB-DTPA in Patients with Varying Degree of Hepatobiliary Disease.
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Objectives To develop and evaluate a procedure for quantifying the hepatocyte-specific uptake of Gd-BOPTA and Gd-EOB-DTPA using dynamic contrast-enhanced (DCE) MRI. Methods Ten healthy volunteers were prospectively recruited and 21 patients with suspected hepatobiliary disease were retrospectively evaluated. All subjects were examined with DCE-MRI using 0.025 mmol/kg of Gd-EOB-DTPA. The healthy volunteers underwent an additional examination using 0.05 mmol/kg of Gd-BOPTA. The signal intensities (SI) of liver and spleen parenchyma were obtained from unenhanced and enhanced acquisitions. Using pharmacokinetic models of the liver and spleen, and an SI rescaling procedure, a hepatic uptake rate, K Hep, estimate was derived. The K Hep values for Gd-EOB-DTPA were then studied in relation to those for Gd-BOPTA and to a clinical classification of the patient’s hepatobiliary dysfunction. Results K Hep estimated using Gd-EOB-DTPA showed a significant Pearson correlation with K Hep estimated using Gd-BOPTA (r = 0.64; P < 0.05) in healthy subjects. Patients with impaired hepatobiliary function had significantly lower K Hep than patients with normal hepatobiliary function (K Hep = 0.09 ± 0.05 min-1 versus K Hep = 0.24 ± 0.10 min−1; P < 0.01). Conclusions A new procedure for quantifying the hepatocyte-specific uptake of T 1-enhancing contrast agent was demonstrated and used to show that impaired hepatobiliary function severely influences the hepatic uptake of Gd-EOB-DTPA. Key Points • The liver uptake of contrast agents may be measured with standard clinical MRI. • Calculation of liver contrast agent uptake is improved by considering splenic uptake. • Liver function affects the uptake of the liver-specific contrast agent Gd-EOB-DTPA. • Hepatic uptake of two contrast agents (Gd-EOB-DTPA, Gd-BOPTA) is correlated in healthy individuals. • This method can be useful for determining liver function, e.g. before hepatic surgery
Ämnesord och genrebeteckningar
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Gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid – Gadobenate Dimeglumine – Dynamic contrast-enhanced MRI – Pharmacokinetics – Liver
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Dahlström, Nils,1969-Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping(Swepub:liu)nilda87
(författare)
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Kihlberg, Johan,1970-Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping(Swepub:liu)johki53
(författare)
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Sandström, PerLinköpings universitet,Hälsouniversitetet,Kirurgi(Swepub:liu)persa07
(författare)
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Brismar, TorkelKarolinska Institutet,Department of Clinical Science, Intervention and Technology at Karolinska Institutet, Division of Medical Imaging and Technology, Karolinska University Hospital in Huddinge, Stockholm, Sweden
(författare)
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Smedby, Örjan,1956-Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet,Röntgenkliniken i Linköping(Swepub:liu)orjsm14
(författare)
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Lundberg, Peter,1958-Östergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiofysik,Medicinsk radiologi,Hälsouniversitetet,Radiofysikavdelningen US,Röntgenkliniken i Linköping(Swepub:liu)petlu11
(författare)
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Linköpings universitetCentrum för medicinsk bildvetenskap och visualisering, CMIV
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Radiology: Springer Berlin/Heidelberg22:3, s. 642-6530938-79941432-1084
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