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- Björck, Hanna M.Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Fysiologi,Hälsouniversitetet (author)
Characterization of Shear-Sensitive Genes in the NormalRat Aorta Identifies Hand2 as a Major Flow-ResponsiveTranscription Factor
- Article/chapterEnglish2012
Publisher, publication year, extent ...
- 2012-12-20
- Public Library of Science (PLoS),2012
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-73954
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73954URI
- https://doi.org/10.1371/journal.pone.0052227DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:125882666URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Objective: Shear forces play a key role in the maintenance of vessel wall integrity. Current understanding regarding shear-dependent gene expression is mainly based on in vitro or in vivo observations with experimentally deranged shear, hence reflecting acute molecular events in relation to flow. Our objective was to determine wall shear stress (WSS) in the rat aorta and study flow-dependent vessel wall biology under physiological conditions.Methods and Results: Animal-specific aortic WSS magnitude and vector direction were estimated using computational fluid dynamic simulation based on aortic geometry and flow information acquired by MRI. Two distinct flow pattern regions were identified in the normal rat aorta; the distal part of the inner curvature being exposed to low WSS and a non-uniform vector direction, and a region along the outer curvature being subjected to markedly higher levels of WSS and a uniform vector direction. Microarray analysis revealed a strong differential expression between the flow regions, particularly associated with transcriptional regulation. In particular, several genes related to Ca2+-signalling, inflammation, proliferation and oxidative stress were among the most highly differentially expressed.Conclusions: Microarray analysis validated the CFD-defined WSS regions in the rat aorta, and several novel flow-dependent genes were identified. The importance of these genes in relation to atherosusceptibility needs further investigation.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- TEKNIK OCH TEKNOLOGIER Maskinteknik Strömningsmekanik och akustik hsv//swe
- ENGINEERING AND TECHNOLOGY Mechanical Engineering Fluid Mechanics and Acoustics hsv//eng
- Aorta
- wall shear stress
- magnetic resonance imaging
- computational fluid dynamics
- gene expression
Added entries (persons, corporate bodies, meetings, titles ...)
- Renner, JohanLinköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Mekanisk värmeteori och strömningslära,Tekniska högskolan(Swepub:liu)johsv80 (author)
- Maleki, ShohrehKarolinska Institutet,Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Sweden (author)
- Nilsson, Siv F.E.Linköpings universitet,Farmakologi,Hälsouniversitetet(Swepub:liu)sivni29 (author)
- Kihlberg, JohanLinköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinsk radiologi,Hälsouniversitetet(Swepub:liu)johki53 (author)
- Folkersen, LasseAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Sweden (author)
- Karlsson, MattsLinköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Mekanisk värmeteori och strömningslära,Tekniska högskolan(Swepub:liu)matka16 (author)
- Ebbers, TinoÖstergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Klinisk fysiologi,Hälsouniversitetet,Fysiologiska kliniken US(Swepub:liu)tineb49 (author)
- Eriksson, PerKarolinska Institutet,Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Sweden (author)
- Länne, TosteÖstergötlands Läns Landsting,Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Fysiologi,Hälsouniversitetet,Thorax-kärlkliniken i Östergötland(Swepub:liu)tosla34 (author)
- Linköpings universitetCentrum för medicinsk bildvetenskap och visualisering, CMIV (creator_code:org_t)
Related titles
- In:PLOS ONE: Public Library of Science (PLoS)7:121932-6203
Internet link
- http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052227
- https://liu.diva-portal.org/smash/get/diva2:479263/FULLTEXT01.pdffulltext:print
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052227&type=printable
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73954
- https://doi.org/10.1371/journal.pone.0052227
- http://kipublications.ki.se/Default.aspx?queryparsed=id:125882666
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