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Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1

Refojo, Damian (author)
Max Planck Inst Psychiat, Munich, Germany
Schweizer, Martin (author)
Max Planck Inst Psychiat, Munich, Germany
Kuehne, Claudia (author)
Max Planck Inst Psychiat, Munich, Germany
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Ehrenberg, Stefanie (author)
Max Planck Inst Psychiat, Munich, Germany
Thoeringer, Christoph (author)
Max Planck Inst Psychiat, Munich, Germany
Vogl, Annette M (author)
Max Planck Inst Psychiat, Munich, Germany
Dedic, Nina (author)
Max Planck Inst Psychiat, Munich, Germany
Schumacher, Marion (author)
Max Planck Inst Psychiat, Munich, Germany
von Wolff, Gregor (author)
Max Planck Inst Psychiat, Munich, Germany
Avrabos, Charilaos (author)
Max Planck Inst Psychiat, Munich, Germany
Touma, Chadi (author)
Max Planck Inst Psychiat, Munich, Germany
Engblom, David (author)
German Canc Res Ctr, Heidelberg, Germany
Schuetz, Guenther (author)
German Canc Res Ctr, Heidelberg, Germany
Nave, Klaus-Armin (author)
Max Planck Inst Expt Med, Gottingen, Germany
Eder, Matthias (author)
Max Planck Inst Psychiat, Munich, Germany
Wotjak, Carsten T (author)
Max Planck Inst Psychiat, Munich, Germany
Sillaber, Inge (author)
Max Planck Inst Psychiat, Munich, Germany
Holsboer, Florian (author)
Max Planck Inst Psychiat, Munich, Germany
Wurst, Wolfgang (author)
Max Planck Inst Psychiat, Munich, Germany
Deussing, Jan M (author)
Max Planck Inst Psychiat, Munich, Germany
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 (creator_code:org_t)
American Association for the Advancement of Science (AAAS), 2011
2011
English.
In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 333:6051, s. 1903-1907
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
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  •  The corticotropin-releasing hormone receptor 1 (CRHR1) critically controls behavioral adaptation to stress and is causally linked to emotional disorders. Using neurochemical and genetic tools, we determined that CRHR1 is expressed in forebrain glutamatergic and gamma-aminobutyric acid-containing (GABAergic) neurons as well as in midbrain dopaminergic neurons. Via specific CRHR1 deletions in glutamatergic, GABAergic, dopaminergic, and serotonergic cells, we found that the lack of CRHR1 in forebrain glutamatergic circuits reduces anxiety and impairs neurotransmission in the amygdala and hippocampus. Selective deletion of CRHR1 in midbrain dopaminergic neurons increases anxiety-like behavior and reduces dopamine release in the prefrontal cortex. These results define a bidirectional model for the role of CRHR1 in anxiety and suggest that an imbalance between CRHR1-controlled anxiogenic glutamatergic and anxiolytic dopaminergic systems might lead to emotional disorders.

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