Interbirth Interval Is Associated With Childhood Type 1 Diabetes Risk

Short interbirth interval has been associated with maternal complications and childhood autism and leukemia, possibly due to deficiencies in maternal micronutrients at conception or increased exposure to sibling infections. A possible association between interbirth interval and subsequent risk of childhood type 1 diabetes has not been investigated. A secondary analysis of 14 published observational studies of perinatal risk factors for type 1 diabetes was conducted. Risk estimates of diabetes by category of interbirth interval were calculated for each study. Random effects models were used to calculate pooled odds ratios (ORs) and investigate heterogeneity between studies. Overall, 2,787 children with type 1 diabetes were included. There was a reduction in the risk of childhood type 1 diabetes in children born to mothers after interbirth intervals andlt;3 years compared with longer interbirth intervals (OR 0.82 [95% CI 0.72-0.93]). Adjustments for various potential confounders little altered this estimate. In conclusion, there was evidence of a 20% reduction in the risk of childhood diabetes in children born to mothers after interbirth intervals andlt;3 years.

Svensson, JannetGlostrup University Hospital (författare)
Waldhoer, ThomasMedical University of Vienna (författare)
Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29 (författare)
Sadauskaite-Kuehne, VaivaLithuanian University of Health Science (författare)
Roberts, Christine LUniversity of Sydney (författare)
Parslow, Roger CUniversity of Leeds (författare)
Wadsworth, Emma J KCardiff University (författare)
Brigis, GirtsRiga Stradins University (författare)
Urbonaite, BroneKaunas University of Medicine (författare)
Schober, EdithMedical University of Vienna (författare)
Devoti, GabrieleUniversity of Lecce (författare)
Ionescu-Tirgoviste, ConstantinN Paulescu Institute Diabet (författare)
de Beaufort, Carine EClin Pediat Luxembourg (författare)
Soltesz, GyulaUniversity of Pecs (författare)
C Patterson, ChrisQueens University of Belfast (författare)
Queens University of BelfastGlostrup University Hospital (creator_code:org_t)

Ingår i:Diabetes: American Diabetes Association61:3, s. 702-7070012-17971939-327X

Av författaren/redakt...: Cardwell, Chris ...; Svensson, Jannet; Waldhoer, Thomas; Ludvigsson, John ...; Sadauskaite-Kueh ...; Roberts, Christi ...; visa fler...; Parslow, Roger C; Wadsworth, Emma ...; Brigis, Girts; Urbonaite, Brone; Schober, Edith; Devoti, Gabriele; Ionescu-Tirgovis ...; de Beaufort, Car ...; Soltesz, Gyula; C Patterson, Chr ...; visa färre...

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