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Cold-induced activa...
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Lim, SharonKarolinska Institutet
(author)
Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-03-01
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Nature Publishing Group,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-76020
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76020URI
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https://doi.org/10.1038/nprot.2012.013DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124170830URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Research Council||Swedish Cancer Foundation||Karolinska Institute Foundation||Karolinska Institute||Torsten Soderbergs Foundation||European Union|222741|European Research Council|250021|
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Exposure of humans and rodents to cold activates thermogenic activity in brown adipose tissue (BAT). This protocol describes a mouse model to study the activation of BAT and angiogenesis in adipose tissues by cold acclimation. After a 1-week exposure to 4 degrees C, adult C57BL/6 mice show an obvious transition from subcutaneous white adipose tissue (WAT) into brown-like adipose tissue (BRITE). The BRITE phenotype persists after continuous cold exposure, and by the end of week 5 BRITE contains a high number of uncoupling protein-1-positive mitochondria, a characteristic feature of BAT. During the transition from WAT into BRITE, the vascular density is markedly increased owing to the activation of angiogenesis. In BAT, cold exposure stimulates thermogenesis by increasing the mitochondrial content and metabolic rate. BAT and the increased metabolic rate result in a lean phenotype. This protocol provides an outstanding opportunity to study the molecular mechanisms that control adipose mass.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Honek, JenniferKarolinska Institutet
(author)
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Xue, YuanKarolinska Institute
(author)
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Seki, TakahiroKarolinska Institutet
(author)
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Cao, ZiquanLinköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet(Swepub:liu)ziqca08
(author)
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Andersson, PatrikKarolinska Institutet
(author)
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Yang, XiaojuanKarolinska Institute
(author)
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Hosaka, KayokoKarolinska Institutet
(author)
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Cao, YihaiKarolinska Institutet,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet(Swepub:liu)yihca64
(author)
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Karolinska InstitutetKarolinska Institute
(creator_code:org_t)
Related titles
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In:Nature Protocols: Nature Publishing Group7:3, s. 606-6151754-21891750-2799
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