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- Mansson Kvarnhammar, AnneKarolinska Institutet,Karolinska Institute (author)
Diminished levels of nasal S100A7 (psoriasin) in seasonal allergic rhinitis: an effect mediated by Th2 cytokines
- Article/chapterEnglish2012
Publisher, publication year, extent ...
- BioMed Central,2012
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:liu-76544
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76544URI
- https://doi.org/10.1186/1465-9921-13-2DOI
- https://lup.lub.lu.se/record/2515897URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:124253589URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Funding Agencies|Swedish Medical Research Council||Swedish Heart-Lung Foundation||Karolinska Institutet||Karolinska University Hospital||LOC||
- Background: S100A7 is an antimicrobial peptide involved in several inflammatory diseases. The aim of the present study was to explore the expression and regulation of S100A7 in seasonal allergic rhinitis (SAR). less thanbrgreater than less thanbrgreater thanMethods: Nasal lavage (NAL) fluid was obtained from healthy controls before and after lipopolysaccharide (LPS) provocation, from SAR patients before and after allergen challenge, and from SAR patients having completed allergen-specific immunotherapy (ASIT). Nasal biopsies, nasal epithelial cells and blood were acquired from healthy donors. The airway epithelial cell line FaDu was used for in vitro experiments. Real-time RT-PCR and immunohistochemistry were used to determine S100A7 expression in nasal tissue and cells. Release of S100A7 in NAL and culture supernatants was measured by ELISA. The function of recombinant S100A7 was explored in epithelial cells, neutrophils and peripheral blood mononuclear cells (PBMC). less thanbrgreater than less thanbrgreater thanResults: Nasal administration of LPS induced S100A7 release in healthy non-allergic subjects. The level of S100A7 was lower in NAL from SAR patients than from healthy controls, and it was further reduced in the SAR group 6 h post allergen provocation. In contrast, ASIT patients displayed higher levels after completed treatment. S100A7 was expressed in the nasal epithelium and in glands, and it was secreted by cultured epithelial cells. Stimulation with IL-4 and histamine repressed the epithelial S100A7 release. Further, recombinant S100A7 induced activation of neutrophils and PBMC. less thanbrgreater than less thanbrgreater thanConclusions: The present study shows an epithelial expression and excretion of S100A7 in the nose after microbial stimulation. The levels are diminished in rhinitis patients and in the presence of an allergic cytokine milieu, suggesting that the antimicrobial defense is compromised in patients with SAR.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
- allergen-specific immunotherapy
- antimicrobial peptide
- epithelium
- lipopolysaccharide
- seasonal allergic rhinitis
- Th2 cytokines
- MEDICINE
- MEDICIN
- Th2 cytokines
- lipopolysaccharide
- seasonal allergic rhinitis
- antimicrobial peptide
- epithelium
- allergen-specific immunotherapy
Added entries (persons, corporate bodies, meetings, titles ...)
- Rydberg, CamillaKarolinska Institutet,Karolinska Institute (author)
- Jarnkrants, MalinKarolinska Institute (author)
- Eriksson, MiaKarolinska Institute (author)
- Uddman, RolfLund University,Lunds universitet,Klinisk och experimentell allergiforskning,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Clinical and Experimental Allergy Research,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups,Skåne University Hospital(Swepub:lu)oron-rud (author)
- Benson, MikaelLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet(Swepub:liu)mikbe05 (author)
- Cardell, Lars-OlafKarolinska Institutet,Karolinska Institute (author)
- Karolinska InstitutetKarolinska Institute (creator_code:org_t)
Related titles
- In:Respiratory Research: BioMed Central13:21465-99211465-993X
Internet link
- https://liu.diva-portal.org/smash/get/diva2:515118/FULLTEXT01.pdffulltext:print
- https://respiratory-research.biomedcentral.com/track/pdf/10.1186/1465-9921-13-2
- https://portal.research.lu.se/files/2085047/2544720.pdfFULLTEXT
- http://dx.doi.org/10.1186/1465-9921-13-2FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76544
- https://doi.org/10.1186/1465-9921-13-2
- https://lup.lub.lu.se/record/2515897
- http://kipublications.ki.se/Default.aspx?queryparsed=id:124253589
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