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  • Nielsen, NiklasHelsingborg Hospital (author)

Target temperature management after out-of-hospital cardiac arrest-a randomized, parallel-group, assessor-blinded clinical trial-rationale and design

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • Elsevier,2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-77540
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77540URI
  • https://doi.org/10.1016/j.ahj.2012.01.013DOI
  • https://lup.lub.lu.se/record/2570274URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Heart and Lung Foundation, Sweden||AFA Insurance Foundation, Sweden||Swedish National Health System (ALF), Sweden||County Council of Skane, Sweden||Stig and Ragna Gorthon Foundation, Sweden||Thure Carlsson Foundation, Sweden||Segerfalk Foundation, Sweden||Gyllenstierna-Krapperup Foundation, Sweden||
  • Background Experimental animal studies and previous randomized trials suggest an improvement in mortality and neurologic function with induced hypothermia after cardiac arrest. International guidelines advocate the use of a target temperature management of 32 degrees C to 34 degrees C for 12 to 24 hours after resuscitation from out-of-hospital cardiac arrest. A systematic review indicates that the evidence for recommending this intervention is inconclusive, and the GRADE level of evidence is low. Previous trials were small, with high risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature management strategy is not known. less thanbrgreater than less thanbrgreater thanMethods The TTM trial is an investigator-initiated, international, randomized, parallel-group, and assessor-blinded clinical trial designed to enroll at least 850 adult, unconscious patients resuscitated after out-of-hospital cardiac arrest of a presumed cardiac cause. The patients will be randomized to a target temperature management of either 33 degrees C or 36 degrees C after return of spontaneous circulation. In both groups, the intervention will last 36 hours. The primary outcome is all-cause mortality at maximal follow-up. The main secondary outcomes are the composite outcome of all-cause mortality and poor neurologic function (cerebral performance categories 3 and 4) at hospital discharge and at 180 days, cognitive status and quality of life at 180 days, assessment of safety and harm. less thanbrgreater than less thanbrgreater thanDiscussion The TTM trial will investigate potential benefit and harm of 2 target temperature strategies, both avoiding hyperthermia in a large proportion of the out-of-hospital cardiac arrest population.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wetterslev, JornCopenhagen University Hospital (author)
  • al-Subaie, NawafUniversity of London St Georges Hospital (author)
  • Andersson, BertilSahlgrens University Hospital (author)
  • Bro-Jeppesen, JohnCopenhagen University Hospital (author)
  • Bishop, GillianCampelltown Hospital (author)
  • Brunetti, IoleIRCCS San Martino University Hospital (author)
  • Cranshaw, JuliusRoyal Bournemouth Hospital (author)
  • Cronberg, TobiasLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)efor-tcr (author)
  • Edqvist, KristinCentral Hospital Karlstad (author)
  • Erlinge, DavidLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)kard-der (author)
  • Gasche, YvanUniversity Hospital Geneva (author)
  • Glover, GuyGuys and St Thomas Hospital (author)
  • Hassager, ChristianCopenhagen University Hospital (author)
  • Horn, JannekeUniversity of Amsterdam (author)
  • Hovdenes, JanOslo University Hospital (author)
  • Johnsson, JesperHelsingborg Hospital (author)
  • Kjaergaard, JesperCopenhagen University Hospital (author)
  • Kuiper, MichaelLeeuwarden Medical Centre (author)
  • Langorgen, JorundHaukeland Hospital (author)
  • Macken, LewisRoyal N Shore Hospital (author)
  • Martinell, LouiseSahlgrens University Hospital (author)
  • Martner, PatrikSahlgrens University Hospital (author)
  • Pellis, ThomasDepartment Intens Care, Pordenone (author)
  • Pelosi, PaoloIRCCS San Martino University Hospital,University of Wales Hospital (author)
  • Petersen, PerÖrebro University Hospital (author)
  • Rundgren, MalinLund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-mrg (author)
  • Saxena, ManojSt George Hospital (author)
  • Svensson, RobertÖstergötlands Läns Landsting,Anestesi- och intensivvårdskliniken VIN (author)
  • Stammet, PascalCentre Hospital Luxembourg (author)
  • Thoren, AndersSahlgrens University Hospital (author)
  • Unden, JohanSkåne University Hospital (author)
  • Walden, AndrewRoyal Berkshire Hospital (author)
  • Wallskog, JesperKungalv Hospital (author)
  • Wanscher, MichaelCopenhagen University Hospital (author)
  • Wise, Matthew PUniversity of Wales Hospital (author)
  • Wyon, NicholasLinköpings universitet,Östergötlands Läns Landsting,Anestesi- och intensivvårdskliniken US,Hälsouniversitetet(Swepub:liu)nicwy22 (author)
  • Aneman, AndersLiverpool Hospital (author)
  • Friberg, HansLund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)efor-hfr (author)
  • Persson, Stefan (author)
  • Helsingborg HospitalCopenhagen University Hospital (creator_code:org_t)

Related titles

  • In:American Heart Journal: Elsevier163:4, s. 541-5480002-87031097-6744

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