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Low risk HLA-DQ and...
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Carlsson, AnnelieLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital SUS,Queen Silvia Childrens Hospital
(författare)
Low risk HLA-DQ and increased body mass index in newly diagnosed type 1 diabetes children in the Better Diabetes Diagnosis study in Sweden
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2011-06-28
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Nature Publishing Group,2012
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-77863
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77863URI
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https://doi.org/10.1038/ijo.2011.122DOI
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https://lup.lub.lu.se/record/2007661URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124579004URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Swedish Child Diabetes Foundation||National Institutes of Health|DK63861DK26190|Swedish Research Council||Swedish Diabetes Association||Knut & Alice Wallenberg Foundation||Lion Club International District 101-S||Skane County Council for Research and Development||
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Objective: Type 1 diabetes and obesity has increased in childhood. We therefore tested the hypothesis that type 1 diabetes human leukocyte antigen DQ (HLA-DQ) risk genotypes may be associated with increased body mass index (BMI). less thanbrgreater than less thanbrgreater thanDesign: The type 1 diabetes high-risk HLA-DQ A1*05:01-B1*02:01/A1*03:01-B1*03:02 genotype along with lower risk DQ genotypes were determined at the time of clinical onset by PCR and hybridization with allele-specific probes. BMI was determined after diabetes was stabilized. less thanbrgreater than less thanbrgreater thanSubjects: A total of 2403 incident type 1 diabetes children below 18 years of age were ascertained in the Swedish national Better Diabetes Diagnosis (BDD) study between May 2005 to September 2009. All children classified with type 1 diabetes, including positivity for at least one islet autoantibody, were investigated. less thanbrgreater than less thanbrgreater thanResults: Overall, type 1 diabetes HLA-DQ risk was negatively associated with BMI (Pandlt;0.0008). The proportion of the highest risk A1*05:01-B1*02:01/A1*03:01-B1*03:02 genotype decreased with increasing BMI (Pandlt;0.0004). However, lower risk type 1 diabetes DQ genotypes were associated with an increased proportion of patients who were overweight or obese (Pandlt;0.0001). Indeed, the proportion of patients with the low-risk A1*05:01-B1*02:01/A1*05:01-B1*02:01 genotype increased with increasing BMI (Pandlt;0.003). The magnitude of association on the multiplicative scale between the A1*05:01-B1*02:01/A1*05:01-B1*02:01 genotype and increased BMI was significant (Pandlt;0.006). The odds ratio in patients with this genotype of being obese was 1.80 (95% confidence interval 1.21-2.61; Pandlt;0.006). The increased proportion of overweight type 1 diabetes children with the A1*05:01-B1*02:01 haplotype was most pronounced in children diagnosed between 5 and 9 years of age. less thanbrgreater than less thanbrgreater thanConclusions: Susceptibility for childhood type 1 diabetes was unexpectedly found to be associated with the A1*05:01-B1*02:01/A1*05:01-B1*02:01 genotype and an increased BMI. These results support the hypothesis that overweight may contribute to the risk of type 1 diabetes in children positive for HLA-DQ A1*05:01-B1*02:01.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kockum, IKarolinska Institutet,Karolinska Institute
(författare)
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Lindblad, BengtLund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups,Queen Silvia Childrens Hospital(Swepub:lu)kir-bli
(författare)
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Engleson, LisaLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital SUS(Swepub:lu)med-len
(författare)
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Nilsson, ALund University
(författare)
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Forsander, GQueen Silvia Childrens Hospital
(författare)
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Karlsson, A-KQueen Silvia Childrens Hospital,Sachs Childrens Hospital
(författare)
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Kernell, ASachs Childrens Hospital
(författare)
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Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29
(författare)
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Marcus, CKarolinska Institutet,Karolinska Institute
(författare)
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Zachrisson, IKarolinska Institutet,Karolinska Institute
(författare)
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Ivarsson, StenLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups(Swepub:lu)pedi-siv
(författare)
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Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)endo-ale
(författare)
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Pediatrik, LundSektion V
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Obesity: Nature Publishing Group36:5, s. 718-7240307-05651476-5497
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Carlsson, Anneli ...
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Kockum, I
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Lindblad, Bengt
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Engleson, Lisa
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Nilsson, A
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Forsander, G
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Karlsson, A-K
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Kernell, A
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Ludvigsson, John ...
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Marcus, C
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Zachrisson, I
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Ivarsson, Sten
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Lernmark, Åke
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