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In type 2 diabetes,...
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Guldbrand, HansLinköpings universitet,Allmänmedicin,Hälsouniversitetet
(författare)
In type 2 diabetes, randomisation to advice to follow a low-carbohydrate diet transiently improves glycaemic control compared with advice to follow a low-fat diet producing a similar weight loss
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2012-05-06
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Springer,2012
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-78537
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-78537URI
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https://doi.org/10.1007/s00125-012-2567-4DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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AIMS/HYPOTHESIS: The study aimed to compare the effects of a 2 year intervention with a low-fat diet (LFD) or a low-carbohydrate diet (LCD), based on four group meetings to achieve compliance. METHODS: This was a prospective randomised parallel trial involving 61 adults with type 2 diabetes consecutively recruited in primary care and randomised by drawing ballots. Patients that did not speak Swedish could not be recruited. The primary outcomes in this non-blinded study were weight and HbA(1c). Patients on the LFD aimed for 55-60 energy per cent (E%) and those on LCD for 20 E% from carbohydrate. RESULTS: The mean BMI and HbA(1c) of the participants were 32.7 ± 5.4 kg/m(2) and 57.0 ± 9.2 mmol/mol, respectively. No patients were lost to follow-up. Weight loss did not differ between groups and was maximal at 6 months: LFD -3.99 ± 4.1 kg (n = 31); LCD -4.31 ± 3.6 kg (n = 30); p < 0.001 within groups. At 24 months, patients on the LFD had lost -2.97 ± 4.9 kg and those on LCD -2.34 ± 5.1 kg compared with baseline (p = 0.002 and p = 0.020 within groups, respectively). HbA(1c) fell in the LCD group only (LCD at 6 months -4.8 ± 8.3 mmol/mol, p = 0.004, at 12 months -2.2 ± 7.7 mmol/mol, p = 0.12; LFD at 6 months -0.9 ± 8.8 mmol/mol, p = 0.56). At 6 months, HDL-cholesterol had increased with the LCD (from 1.13 ± 0.33 mmol/l to 1.25 ± 0.47 mmol/l, p = 0.018) while LDL-cholesterol did not differ between groups. Insulin doses were reduced in the LCD group (0 months, LCD 42 ± 65 E, LFD 39 ± 51 E; 6 months, LCD 30 ± 47 E, LFD 38 ± 48 E; p = 0.046 for between-group change). CONCLUSIONS/INTERPRETATION: Weight changes did not differ between the diet groups, while insulin doses were reduced significantly more with the LCD at 6 months, when compliance was good. Thus, aiming for 20% of energy intake from carbohydrates is safe with respect to cardiovascular risk compared with the traditional LFD and this approach could constitute a treatment alternative. TRIAL REGISTRATION: ClinicalTrials.gov NCT01005498 FUNDING: University Hospital of Linköping Research Funds, Linköping University, the County Council of Östergötland, and the Diabetes Research Centre of Linköping University.
Ämnesord och genrebeteckningar
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Blood glucose – Dietary intervention – HDL-cholesterol – LDL-cholesterol – Low-carbohydrate diet – Type 2 diabetes
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Dizdar, B.Linköpings universitet,Allmänmedicin,Hälsouniversitetet
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Bunjaku, B.Linköpings universitet,Allmänmedicin,Hälsouniversitetet
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Lindström, TorbjörnLinköpings universitet,Internmedicin,Endokrinologi,Hälsouniversitetet(Swepub:liu)torli22
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Bachrach-Lindström, MargaretaLinköpings universitet,Omvårdnad,Hälsouniversitetet(Swepub:liu)marba57
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Fredrikson, MatsLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Hälsouniversitetet(Swepub:liu)matfr43
(författare)
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Östgren, Carl JohanÖstergötlands Läns Landsting,Linköpings universitet,Allmänmedicin,Hälsouniversitetet,Primärvården i västra länsdelen(Swepub:liu)caros18
(författare)
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Nyström, Fredrik H.Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Endokrinologi,Hälsouniversitetet,Endokrinmedicinska kliniken(Swepub:liu)freny92
(författare)
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Linköpings universitetAllmänmedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Diabetologia: Springer55:8, s. 2118-21270012-186X1432-0428
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