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Redistribution of i...
Redistribution of intracellular Ca2+ stores during phagocytosis in human neutrophils
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- Stendahl, Olle (author)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
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- Krause, Karl-Heins (author)
- Division of Infectious Diseases, Hôpital Cantonal Universitaire, Switzerland
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- Krischer, Joachim (author)
- Department of Morphology, Centre Medical Universitaire, Switzerland
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- Jerström, Petra (author)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
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- Theler, Jean-Marc (author)
- Clinical Biochemistry, Centre Medical Universitaire, Switzerland
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- Clark, Rober A. (author)
- Department of Medicine, VA Medical Center and University of Iowa, USA
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- Carpentier, Jean-Louis (author)
- Department of Morphology, Centre Medical Universitaire, Switzerland
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- Lew, Daniel P. (author)
- Division of Infectious Diseases, Hôpital Cantonal Universitaire, Switzerland
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 1994
- 1994
- English.
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 265:5177, s. 1439-1441
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Subcellular gradients of cytosolic free Ca2+ concentration, [Ca2+]i, are thought to be critical for the localization of functional responses within a cell. A potential but previously unexplored mechanism for the generation of gradients of [Ca2+]i is the accumulation of Ca2+ stores at the site of Ca2+ action. The distribution of the Ca2+ store markers Ca(2+)-dependent adenosine triphosphatase and calreticulin was investigated in resting and phagocytosing human neutrophils. Both proteins showed an evenly distributed fine granular pattern in nonphagocytosing cells, but became markedly concentrated in the filamentous actin-rich cytoplasmic area around the ingested particle during phagocytosis. This redistribution began at early stages of phagocytosis and did not depend on an increase in [Ca2+]i. Thus, accumulation of Ca2+ stores in a restricted area of the cell may contribute to the generation of localized increases in [Ca2+]i.
Keyword
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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