Functional Regeneration of C-Fibries Inside a Silicone Tube After Sciatic Neurotomy in Rats

• Peripheral nerve lesions are often complicated by difficulties in approximating the nerve tumps without tension. The aim of the present study was to evaluate C-fïbre function after nerve regeneration in rats in which the nerve had been lengthened by leaving a 5 mm gap inside a silicone tube (n = 5). The outcome was compared with nerve regeneration after epineural end-to-end suture (n = 5). The innervated skin territory was defined by Evans blue extravasation after antidromic nerve stimulation. Five rats acted as controls. After three months, there was similar functional reinnervation in both experimental groups, which indicates that silicone tubes may reduce tension over a nerve repair with no adverse effects.

Keyword

rat

neurotomy

silicone tube

defect

epineural suture

nociceptors

MEDICINE

MEDICIN

Publication and Content Type

ref (subject category)

art (subject category)