Search: (AMNE:(MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området)) srt2:(2010-2014)
> (2012) >
Biomarkers of Coagu...
Biomarkers of Coagulation, Inflammation, and Angiogenesis are Independently Associated with Preeclampsia
-
- Boij, Roland (author)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
-
- Svensson, Judit (author)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
-
- Nilsson-Ekdahl, Kristina (author)
- Linnéuniversitetet,Uppsala universitet,Klinisk immunologi,Institutionen för naturvetenskap, NV,Uppsala University, Sweden Linneaus University, Sweden
-
show more...
-
- Sandholm, Kerstin (author)
- Linnéuniversitetet,Institutionen för naturvetenskap, NV,Linneaus University, Sweden
-
- Lindahl, Tomas (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk kemi,Hälsouniversitetet
-
- Palonek, Elzbieta (author)
- Karolinska University Hospital, Sweden Doping Control Lab, Sweden
-
- Garle, Mats (author)
- Karolinska University Hospital, Sweden Doping Control Lab, Sweden
-
- Berg, Göran (author)
- Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping
-
- Ernerudh, Jan (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin
-
- Jenmalm, Maria (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
-
- Matthiesen, Leif (author)
- Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping
-
Berg, Mats (author)
-
Jenmalm, Mats (author)
-
show less...
-
(creator_code:org_t)
- 2012-05-24
- 2012
- English.
-
In: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. - : John Wiley and Sons. - 1046-7408 .- 8755-8920. ; 68:3, s. 258-270
- Related links:
-
https://liu.diva-por... (primary) (Raw object)
-
show more...
-
http://liu.diva-port...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Problem Although preeclampsia has been associated with inflammation, coagulation, and angiogenesis, their correlation and relative contribution are unknown. Method of Study About 114 women with preeclampsia, 31 with early onset (EOP) and 83 with late onset preeclampsia (LOP), and 100 normal pregnant controls were included. A broad panel of 32 biomarkers reflecting coagulation, inflammation, and angiogenesis was analyzed. Results Preeclampsia was associated with decreased antithrombin, IL-4 and placental growth factor levels and with increased C3a, pentraxin-3, and sFlt-1 levels, with more marked differences in the EOP group. The Th1-associated chemokines CXCL10 and CXCL11 were significantly higher in the preeclampsia and EOP group than in controls, respectively. No correlations between the biomarkers were found in preeclampsia. Multivariate logistic regression tests confirmed the results. Conclusions Cytokines, chemokines and complement activation seem to be part of a Th1-like inflammatory reaction in preeclampsia, most pronounced in EOP, where chemokines may be more useful than cytokines as biomarkers. Biomarkers were not correlated suggesting partly independent or in time separated mechanisms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- preeclampsia
- coagulation
- inflammation
- angiogenesis
- chemokines
- cytokines and early onset preeclampsia
- MEDICINE
- MEDICIN
- Immunologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Boij, Roland
-
Svensson, Judit
-
Nilsson-Ekdahl, ...
-
Sandholm, Kersti ...
-
Lindahl, Tomas
-
Palonek, Elzbiet ...
-
show more...
-
Garle, Mats
-
Berg, Göran
-
Ernerudh, Jan
-
Jenmalm, Maria
-
Matthiesen, Leif
-
Berg, Mats
-
Jenmalm, Mats
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
AMERICAN JOURNAL ...
- By the university
-
Linköping University
-
Uppsala University
-
Linnaeus University